Results 91 to 100 of about 2,307,247 (300)
PhotonicsThe wide application of displacement measurement in high-precision equipment production and high-precision metrology is placing increasing pressure on the resolution of heterodyne interferometers.
Yunke Sun +5 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Perceived Exertion and Stimulus Intensity Modulation
, 1977 Perceptual augmentation and reduction were considered contrasting styles of Stimulus Intensity Modulation. Differences in perceived exertion between augmenters and reducers were determined for three cycle ergometer work loads.
Robert L. Gillespie +3 more
core +1 more source
Analogue photonic link design charts for microwave engineering applications
The Journal of Engineering, 2015 A set of unique design charts for intensity-modulation direct-detection microwave photonics links is presented. The charts facilitate link design and analysis, clearly demonstrating performance trade-offs in terms of standard microwave performance ...
Vincent J. Urick
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
IEEE AccessThe precise regulation of wavelength and intensity of infrared (IR) light is crucial in medical applications, as it influences tissue penetration depth, therapeutic specificity, and treatment safety.
Uttara Biswas +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Galactic cosmic ray modulation near the heliospheric current sheet [PDF]
, 2014 Galactic cosmic rays (GCRs) are modulated by the heliospheric magnetic field (HMF) both over decadal time scales (due to long-term, global HMF variations), and over time scales of a few hours (associated with solar wind structures such as coronal mass ...
Owens, M. J. +7 more
core +1 more source
Interferometrically Enhanced Intensity and Wavelength Modulation in Tunable Diode Laser Spectroscopy
PhotonicsTunable diode laser spectroscopy (TDLS) is a measurement technique with high spectral resolution. It is based on tuning the emission wavelength of a semiconductor laser by altering its current and/or its temperature.
Sander Vervoort, Marcus Wolff
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source