Results 101 to 110 of about 816,203 (299)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A Picometre-Level Resolution Test Method without Nonlinearity for Heterodyne Interferometer Measurement Electronics

Photonics
The wide application of displacement measurement in high-precision equipment production and high-precision metrology is placing increasing pressure on the resolution of heterodyne interferometers.
Yunke Sun, Wenjun Li, Xu Xing, Jianing Wang, Pengcheng Hu, Jiubin Tan   +5 more
doaj   +1 more source

Demonstration of input-to-output gain and temporal noise mitigation in a Talbot amplifier

, 2017
We experimentally demonstrate intensity amplification of repetitive picosecond optical pulses with an input-to-output gain up to 5.5 dB using a passive Talbot amplifier.
Azana, Jose, Cortes, Luis Romero, Jeon, Jinwoo, Li, Xiao-Zhou, Maram, Reza, Seghilani, Mohamed, van Howe, James   +6 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Intensity modulation and direct detection quantum key distribution based on quantum noise

New Journal of Physics, 2016
Quantum key distribution (QKD) has been studied for achieving perfectly secure cryptography based on quantum mechanics. This paper presents a novel QKD scheme that is based on an intensity-modulation and direct-detection system.
Takuya Ikuta, Kyo Inoue
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Longitudinal piezoelectric resonant photoelastic modulator for efficient intensity modulation at megahertz frequencies. [PDF]

Nat Commun, 2022
Atalar O, Van Laer R, Safavi-Naeini AH, Arbabian A.   +3 more
europepmc   +1 more source

Experimental study of the delayed threshold phenomenon in a semiconductor laser

, 2012
An experimental study of the delayed threshold phenomenon in a Vertical Extended Cavity Semiconductor Emitting Laser is carried out. Under modulation of the pump power, the laser intensity exhibits a hysteresis behavior in the vicinity of the threshold ...
A. El Amili, Arecchi, Aronowitz, Baili, Baili, Baili, Balestri, Björk, Chakmakjian, Ciofini, Erneux, F. Bretenaker, G. Gredat, Henry, Hong, Hong, I. Sagnes, Laurain, M. Alouini, Mandel, Mandel, Mikhnenko, Rice, Sharpf, Tredicce, Vemuri   +25 more
core   +4 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Enhanced Performance of Intensity Modulation With Direct Detection Using Golay Encoded Nyquist Pulses and Electronic Dispersion Compensation

IEEE Photonics Journal
The performance of intensity modulation (IM) with direct detection (DD) transmission systems is enhanced through a novel combination of multidimensional coding, Nyquist pulse shaping, and electronic dispersion compensation (EDC) at the transmitter using ...
Julien Moussa H. Barakat, Abdul Rahman El Falou, Zeynep Nilhan Gurkan, Shadi A. Alboon, Abdullah S. Karar   +4 more
doaj   +1 more source