Results 81 to 90 of about 2,307,247 (300)

An open-path, hand-held laser system for the detection of methane gas [PDF]

, 2005
We have developed an open-path hand-held gas detector incorporating a distributed feedback InGaAs laser diode at 1.65 µm. Incorporated into a hand-held transceiver unit, the emitted laser beam is backscattered from nearby surfaces, collected and focused ...
Padgett, M, Murray, S, van Well, Ben, Gibson, G, Strzoda, Rainer, Padgett, Miles, van Well, B, Hodgkinson, Jane, Pride, Russ D., Murray, Stuart, Gibson, Graham, Strzoda, R, Pride, R, Hodgkinson, J   +13 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

On the study of the FSO link performance under controlled turbulence and fog atmospheric conditions [PDF]

, 2011
In this paper, the effect of turbulence and fog on the free space optical (FSO) communication systems for on off keying (OOK), pulse amplitude modulation (PAM) and subcarrier intensity modulation (SIM) based on binary phase shift keying (BPSK) is ...
Ghassemlooy, Zabih, Kandus, Gorazd, Kvicera, V., Leitgeb, Erich, Rajbhandari, Sujan, Perez Soler, Joaquin, Le Minh, Hoa   +6 more
core  

Quasi-periodic modulation of equatorial noise intensity

, 2015
International audienceEquatorial noise (EN) emissions are electromagnetic waves at frequencies between the proton cyclotron frequency and the lower hybrid frequency observed routinely in the equatorial region of the inner magnetosphere. They propagate in
Hrbackova, Z., Nemec, F., Santolík, O., Cornilleau-Wehrlin, Nicole, Pickett, J. S.   +4 more
core   +5 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Power Efficient Subcarrier Modulation for Intensity Modulated Channels

Optics Express, 2010
We compare formats for optical intensity modulation limited by thermal noise with the assumption of having ideal devices. At the same bitrate and bandwidth, a hitherto unknown format turns out to be more power efficient than known formats. This new modulation, which is a hybrid between on-off keying and phase-shift keying, belongs to the subcarrier ...
Johnny, Karout, Erik, Agrell, Magnus, Karlsson   +2 more
openaire   +2 more sources

The 22-Year Hale Cycle in Cosmic Ray Flux – Evidence for Direct Heliospheric Modulation [PDF]

, 2014
The ability to predict times of greater galactic cosmic ray (GCR) fluxes is important for reducing the hazards caused by these particles to satellite communications, aviation, or astronauts.
Thomas, SR, Lockwood, M, Owens, MJ
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Wavelength modulation spectroscopy: combined frequency and intensity laser modulation [PDF]

A theoretical model of wavelength modulation spectroscopy that uses a laser diode on a Lorentzian absorption line is presented. This theory describes the general case of a current-modulated semiconductor laser for which a combined intensity and frequency
Thévenaz, Luc, Schilt, S., Robert, P.
core   +2 more sources