Results 121 to 130 of about 816,203 (299)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Outcome of Adenoid Cystic Carcinoma of Head and Neck After Postoperative Intensity Modulation Radiotherapy: A Single Institution Study. [PDF]

Cancer Manag Res, 2021
Xu P, Wang S, Luo Y, Yin J, Belkacemi Y, Lu S, Feng M, Lang J.   +7 more
europepmc   +1 more source

Solar cycle variations of the anomalous cosmic ray component [PDF]

The intensity of the anomalous cosmic ray component, consisting of He, N, O, and Ne, has long been known to be especially sensitive to the effects of solar modulation.
Mewaldt, R. A., Stone, E. C.
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Time Span of an Image Frame Using a CMOS Sensor in Rolling Shutter‐Based Optical Camera Communications

IET Optoelectronics
In this paper, a rolling shutter optical camera communication system is investigated by analysing the internal working principle of a receiver based on complementary metal oxide semiconductor image sensors.
Raul Zamorano‐Illanes, Zabih Ghassemlooy, Xicong Li, Othman Younus, Stanislav Zvánovec, Ismael Soto   +5 more
doaj   +1 more source

New results from long-term observations of Cyg X-1 [PDF]

Observations of Cyg X-1 between October 1974 and July 1975 reveal a persistent 5.6 day modulation of the 3 to 6 keV X-ray intensity, having a minimum in phase with superior conjunction of the HDE 226868 binary system.
Boldt, E. A., Holt, S. S., Kaluzienski, L. J., Serlemitsos, P. J.   +3 more
core   +1 more source

Self Phase Modulation and Stimulated Raman Scattering due to High Power Femtosecond Pulse Propagation in Silicon-on-Insulator Waveguides. [PDF]

, 2005
Self Phase Modulation (SPM) and Stimulated Raman Scattering (SRS) in silicon waveguides have been observed and will be discussed theoretically using a modified Nonlinear Schrödinger Equation.
Ctyroky, J., Dekker, R., Driessen, A., Först, M., Klein, E.J., Niehusmann, J., Ondracek, F., Usechak, N.   +7 more
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source