Results 91 to 100 of about 3,790,950 (369)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Flavored circular collider: cornering New Physics at FCC-ee via flavor-changing processes

European Physical Journal C: Particles and Fields
We illustrate the potential of a future high-intensity $$e^+ e^-$$ e + e - collider running at the Z pole in probing extensions of the Standard Model via precise measurements of flavor-changing processes.
Lukas Allwicher, Gino Isidori, Marko Pesut   +2 more
doaj   +1 more source

Physics prospects with an intense neutrino experiment [PDF]

AIP Conference Proceedings, 2000
6 pages, 1 figure, 2 tables, Preseted at CIPANP 2000 May 22-28 Quebec City ...
openaire   +2 more sources

MODERATE INTENSITY PHYSICAL EXERCISE: PSYCHONEUROIMMUNOLOGICAL ASPECTS [PDF]

Revista Brasileira de Medicina do Esporte, 2018
ABSTRACT The literature presents several instances of interaction between the nervous system (NS) and the immune system (IS). These interactions are promoted by several molecules, such as cytokines and hormones, with modulating action for both the NS and IS. In this sense, the two systems may influence each other: changes in behavior may be accompanied
Eduardo Vignoto Fernandes, Celio Estanislau, Emerson José Venancio   +2 more
openaire   +3 more sources

Strong laser fields as a probe for fundamental physics

, 2008
Upcoming high-intensity laser systems will be able to probe the quantum-induced nonlinear regime of electrodynamics. So far unobserved QED phenomena such as the discovery of a nonlinear response of the quantum vacuum to macroscopic electromagnetic fields
A. Dupays, A. Melchiorri, A. Piazza Di, A.S. Chou, B. Batell, B. Holdom, C. Robilliard, D.J. Kapner, E. Alp, E. Masso, E. Zavattini, E.G. Adelberger, G.V. Dunne, G.V. Dunne, H. Gies, H. Gies, H. Gies, H. Gies, H. Gies, I. Antoniadis, J. Jaeckel, J. Khoury, J.K. Daugherty, J.S. Schwinger, L. Maiani, M. Ahlers, M. Ahlers, M. Ahlers, P. Sikivie, R. Cameron, R. Foot, R. Schutzhold, R.D. Peccei, R.N. Mohapatra, S. Andriamonje, S. Davidson, S. Gordienko, S.A. Abel, S.L. Adler, T. Heinzl, V. Baier, V. Weisskopf, W. Dittrich, W. Heisenberg   +43 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Precipitation Characteristics in the Community Atmosphere Model and Their Dependence on Model Physics and Resolution

Journal of Advances in Modeling Earth Systems, 2019
Precipitation amount (A), frequency (F), intensity (I), and duration (D) are important properties of precipitation, but their estimates are sensitive to data resolution.
Di Chen, Aiguo Dai
doaj   +1 more source

Assessing physical activity intensity by video analysis

Physiological Measurement, 2015
Assessing physical activity (PA) is a challenging task and many different approaches have been proposed. Direct observation (DO) techniques can objectively code both the behavior and the context in which it occurred, however, they have significant limitations such as the cost and burden associated with collecting and processing data.
P, Silva, C, Santiago, L P, Reis, A, Sousa, J, Mota, G, Welk   +5 more
openaire   +3 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source