Results 91 to 100 of about 5,122,361 (303)
Advanced Science, EarlyView.Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu +12 more
wiley +1 more source
Advanced Science, EarlyView.Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng +15 more
wiley +1 more source
Neurotrauma ReportsEarly extubation is considered to be beneficial for pre-term neonates. On the other hand, premature extubation can cause lung derecruitment, compromised gas exchange, and need for reintubation, which may be associated with severe brain injury caused by ...
Paolo Massirio +14 more
doaj +1 more source
Embryological development of the intestine and necrotizing enterocolitis
Journal of Pediatric and Neonatal Individualized Medicine, 2016 It is possible to distinguish two phases in the development and maturation of the intestine: intra-uterine and extra-uterine. Up until the 13th week of the embryological phase, a fetus’ development is not controlled by factors external to the alimentary
Anna De Magistris +6 more
doaj +1 more source
Advanced Science, EarlyView.Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng +14 more
wiley +1 more source
Italian Journal of PediatricsBackground Advances in neonatal medicine have improved survival rates in neonatal intensive care units, especially for high-complexity cases like congenital diaphragmatic hernia (CDH).
Sara Ronci +10 more
doaj +1 more source
Advanced Science, EarlyView.GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko +5 more
wiley +1 more source
Neonatal enteral feeding tube as loci for Enterobacteriaceae colonisation and risk to neonatal health [PDF]
, 2014 The incidence of neonatal infections caused by Enterobacteriaceae has been increasing in recent years, and they are now recognised as the predominant causative agents in neonatal intensive care unit (NICU) outbreaks. Klebsiella spp. and Serratia spp. are
Abudalla, H
core
The lived experiences of mothers regarding care of their hospitalised preterm babies [PDF]
, 2011 Includes abstract.Includes bibliographical references (leaves 106-121).Trends in neonatal care aim to minimise separation of the baby from the mother in an effort to promote the well-being of both the mother and the baby, with proven positive effects on ...
Ncube, Rosinah Kereemang
core +1 more source
Nutritional and metabolic programming during the first thousand days of life
La Pediatria Medica e Chirurgica, 2017 The latest scientific acquisitions are demonstrating what has already been hypothesized for more than twenty years about the development of the state of health/illness of individuals. Indeed, certain stimuli, if applied to a sensible phase of development,
Massimo Agosti +3 more
doaj +1 more source