Results 81 to 90 of about 5,122,361 (303)

Investigate the effects of donor breast milk and formula milk on metabolites in preterm infants through non-targeted metabolomics

BMC Nutrition
Background Preterm infants’ underdeveloped gastrointestinal and immune systems increase their risk of life-threatening complications like necrotizing enterocolitis (NEC).
Fei Yang, Yanfeng Zhao, Ying Zhang, Chunyu Zhang   +3 more
doaj   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Virulence potential of enterobacteriaceae isolated from neonatal enternal feeding tubes [PDF]

, 2013
In recent years, there has been a rise in the incidence of neonatal infections due to Enterobacteriaceae including Escherichia coli, Enterobacter, Klebsiella and Serratia spp.
Alkeskas, AA
core  

Melatonin Suppresses NLRP3 Inflammasome Activation via SIRT1-Mediated ETS1 Deacetylation to Attenuate LPS-Induced Pyroptosis in Alveolar Epithelial Cells

Journal of Inflammation Research
Fan He, Chunzi Liu, Yun Yu, Qiaofang Wang, Lin Li, Xiaoyun Chao, Liping Chen, Cong Yu Neonatal Intensive Care Unit, Jiangxi Provincial Children’s Hospital, Nanchang, Jiangxi, 330038, People’s Republic of ChinaCorrespondence: Liping Chen, Neonatal ...
He F, Liu C, Yu Y, Wang Q, Li L, Chao X, Chen L, Yu C   +7 more
doaj  

Acute kidney injury in neonatal age

Journal of Pediatric and Neonatal Individualized Medicine, 2014
Acute kidney injury (AKI) is a pathology characterized by a sudden decrease in kidney function that results in the accumulation of nitrogenous waste products and alteration of the regulation of extracellular fluid volume, electrolytes, and acid-base ...
Giovanni Ottonello, Angelica Dessì, Paola Neroni, Maria Elisabetta Trudu, Danila Manus, Vassilios Fanos   +5 more
doaj   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Relationship between Maternal Stress and Neurobehavioral Indicators of Preterm Infants in the Neonatal Intensive Care Unit

Background: Preterm birth and prolonged neonatal hospitalization are potential sources of stress for mothers of preterm and low birth weight infants. Aim: To evaluate maternal stress and its association with neurobehavioral indicators of preterm infants ...
Patricia Gonçalves Evangelista Marçal, Cibelle Kayenne Martins Roberto Formiga, Waldemar Naves do Amaral, Bruna Abreu Ramos, Nayara Rodrigues Gomes de Oliveira, Tárik Kassem Saidah, Rui Gilberto Ferreira   +6 more
core   +1 more source

Periostin‐CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy

Advanced Science, EarlyView.
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Tiantian Wu, Ruotong Li, Xiaoyue Zhang, Dandan Chen, Jianmeng Yang, Mengmeng Li, Yuhan Yin, Ya Wang, Yuqiu Tian, Haoling Yan, Dan Cui, Jiangping Song, Gaoliang Ouyang   +12 more
wiley   +1 more source

Peripheral perfusion index-reference range in healthy Portuguese term newborns

Journal of Pediatric and Neonatal Individualized Medicine, 2014
Introduction: Peripheral perfusion index (PPI) is a non-invasive numerical value of peripheral perfusion derived from a pulse oximeter signal. It has been suggested that PPI may be a valuable adjunct diagnostic tool to detect early clinically significant
Joana Jardim, Ruben Rocha, Gorett Silva, Hercília Guimarães   +3 more
doaj   +1 more source