Results 101 to 110 of about 5,122,361 (303)

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

The Ethics of Research in the Neonatal Intensive Care Unit

, 1996
The speciality of neonatal intensive care is one in which there is rapid expansion of knowledge and technology.  It is an area where the barriers of critical illness and gestational immaturity are constantly being challenged, innovative treatments ...
Sarah Gamble
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Cultura de segurança do paciente em unidades de terapia intensiva neonatal [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Enfermagem, Florianópolis, 2013.A cultura de segurança do paciente é discutida mundialmente sendo considerada um elemento essencial
Tomazoni, Andréia
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Determinants of Extended Neonatal Intensive Care Unit Stay [PDF]

Iranian Journal of Neonatology
Background: Prolonged hospitalization in the Neonatal Intensive Care Unit (NICU) escalates healthcare costs and potentially exposes neonates to further complications. This study aimed to identify the significant predictors influencing the length of stay (
Ridha Rahmah, Alfatah Rifky, Nadia Anisha, Nabila Khansa, Indra Sandinirwan   +4 more
doaj   +1 more source

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Conceptual framework. ICU, intensive care unit; NICU, neonatal intensive care unit.

, 2016
Conceptual framework. ICU, intensive care unit; NICU, neonatal intensive care unit.
David Macleod (2557612), Luca Cegolon (2557609), Lenka Benova (168877), Oona M. R. Campbell (107725)   +3 more
core   +1 more source

From the “old NEC” to the “new NECs”

Journal of Pediatric and Neonatal Individualized Medicine, 2014
Necrotizing enterocolitis (NEC) is an acute inflammatory disease of the neonatal intestine that strikes in 1 of 1,000 live births. Its etiology is unknown.
Melania Puddu, Maria Antonietta Marcialis, Anna De Magistris, Roberta Irmesi, Elisabetta Coni, Luigi Mascia, Vassilios Fanos   +6 more
doaj   +1 more source

Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis

Advanced Science, EarlyView.
OSMR mutations disrupt STAT5 signaling and AKR1B10‐mediated lipid metabolism, leading to lipid accumulation and protein aggregation in keratinocytes. This metabolic reprogramming drives amyloid deposition in primary localized cutaneous amyloidosis, revealing a mechanistic link between lipid dysregulation and amyloidogenesis.
Huiting Liu, Wen Zheng, Chao Yang, Tao Yang, Qiuyu Chen, Ping Lu, Huan Yang, Jun Liu, Bin Yang   +8 more
wiley   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Knowledge and attitudes of neonatal intensive care nurses toward assessment and management of pain

, 1997
Due to technologic breakthroughs, neonatal intensive care units (NICU) are caring for sicker and tinier clients. However, personal beliefs and attitudes about neonatal pain have not kept up with the times.
Walls, Ingeborg C.
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