Results 141 to 150 of about 698,716 (345)

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations

Advanced Science, EarlyView.
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi, Mohamed Ramadan, Lu Yu, Fengjiao Hui, Amjad Hussain, Xiaofeng Zhou, Yu Yu, Xianlong Zhang, Shuangxia Jin   +8 more
wiley   +1 more source

Floppy Infant Syndrome: new approach to the study of neonatal hypotonia through the analysis of a rare case of X-Linked Myotubular Myopathy

Journal of Pediatric and Neonatal Individualized Medicine, 2014
The Floppy Infant Syndrome includes a variety of signs and symptoms: decrease in muscle tone (hypotonia), in muscle power (weakness) and ligamentous laxity and increased range of joint mobility.
Massimiliano De Vivo, Silvana Rojo, Roberto Rosso, Giovanni Chello, Paolo Giliberti   +4 more
doaj   +1 more source

Exploring the gap between needs and practice in facilitating breastfeeding within the neonatal intensive care setting : An Italian survey on organizational factors [PDF]

, 2019
Introduction: The system-level factors of the neonatal intensive care unit work environment contribute to breastfeeding promotion in the preterm population.
D. Morniroli, E. Bezze, E. Tambani, F. Mosca, G. Sorrentino, L. Plevani, M. Gianni, P. Sannino   +7 more
core   +1 more source

Bionic Microneedle Patch Inspired by Drosophila Tarsal Paws Boosts Healing in Bacterial Infectious Stomatitis

Advanced Science, EarlyView.
Microneedle suction cup patches, prepared using bionic Drosophila tarsal claws, can effectively treat bacterial infectious stomatitis by rapidly and efficiently leveraging multiple effects, including antibacterial and anti‐inflammatory properties, promotion of vasodilation, and active mechanical contraction of the wound.
Jiaqi Qin, Cewen Hu, Xiaohong Ran, Huajing Zeng, Jie Zhang, Bin Liu, Zengjie Fan   +6 more
wiley   +1 more source

Case histories of five years of neonatal urinary tract infections: practical aspects of treatment and the need for agreed-upon guidelines

Journal of Pediatric and Neonatal Individualized Medicine, 2012
Case series of urinary tract infection (UTI) in neonates (0 to 1 month of life) hospitalized in the neonatal care unit of Cagliari’s university hospital during a five-year period.
Giovanni Ottonello, Angelica Dessì, Giuseppe Masnata, Marcella Peri, Alice Melis, Vassilios Fanos   +5 more
doaj   +1 more source

Paediatric intensive care and neonatal intensive care airway management in the United Kingdom: the PIC‐NIC survey

Anaesthesia, 2018
In 2011, the Fourth National Audit Project (NAP4) reported high rates of airway complications in adult intensive care units (ICUs), including death or brain injury, and recommended preparation for airway difficulty, immediately available difficult airway
K. E. Foy, E. Mew, T. M. Cook, J. Bower, P. Knight, S. Dean, K. Herneman, B. Marden, F. E. Kelly   +8 more
semanticscholar   +1 more source

Short-Term Neurodevelopmental Outcome in Term Neonates Treated with Phenobarbital versus Levetiracetam: A Single-Center Experience [PDF]

, 2019
BACKGROUND: Phenobarbital (PB) has been traditionally used as the first-line treatment for neonatal seizures. More recently, levetiracetam (LEV) has been increasingly used as a promising newer antiepileptic medication for treatment of seizures in ...
Barbagallo, M., Corsello, G., Falsaperla, R., Mauceri, L., Pavone, P., Pisani, F., Ruggieri, M., Vitaliti, G.   +7 more
core   +3 more sources

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

What you have to know about Human Milk Oligosaccharides

Journal of Pediatric and Neonatal Individualized Medicine, 2018
Human Milk Oligosaccharides (HMOs), the third most important solid components of BM (the first and the second being lactose and lipids respectively), are a highly variable family of unconjugated glycans related to many pathophysiological short- and long ...
Vassilios Fanos, Alessandra Reali, Maria Antonietta Marcialis, Flaminia Bardanzellu   +3 more
doaj   +1 more source

Parents' presence and parent–infant closeness in 11 neonatal intensive care units in six European countries vary between and within the countries

Acta paediatrica, 2017
Little is known about the amount of physical parent–infant closeness in neonatal intensive care units (NICUs), and this study explored that issue in six European countries.
Simo Raiskila, A. Axelin, L. Toome, Sylvia Caballero, B. S. Tandberg, R. Montirosso, E. Normann, B. Hallberg, B. Westrup, U. Ewald, L. Lehtonen   +10 more
semanticscholar   +1 more source