Results 81 to 90 of about 270,776 (287)

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

open access: yesAdvanced Science, EarlyView.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang   +6 more
wiley   +1 more source

Ventilatory Support, Extubation, and Cerebral Perfusion Changes in Pre-Term Neonates: A Near Infrared Spectroscopy Study

open access: yesNeurotrauma Reports
Early extubation is considered to be beneficial for pre-term neonates. On the other hand, premature extubation can cause lung derecruitment, compromised gas exchange, and need for reintubation, which may be associated with severe brain injury caused by ...
Paolo Massirio   +14 more
doaj   +1 more source

Nutritional and metabolic programming during the first thousand days of life

open access: yesLa Pediatria Medica e Chirurgica, 2017
The latest scientific acquisitions are demonstrating what has already been hypothesized for more than twenty years about the development of the state of health/illness of individuals. Indeed, certain stimuli, if applied to a sensible phase of development,
Massimo Agosti   +3 more
doaj   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

open access: yesAdvanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng   +9 more
wiley   +1 more source

Determinants of Extended Neonatal Intensive Care Unit Stay [PDF]

open access: yesIranian Journal of Neonatology
Background: Prolonged hospitalization in the Neonatal Intensive Care Unit (NICU) escalates healthcare costs and potentially exposes neonates to further complications. This study aimed to identify the significant predictors influencing the length of stay (
Ridha Rahmah   +4 more
doaj   +1 more source

Epidemiology of procedural pain in neonatal intensive care units of Portugal [PDF]

open access: yes, 2015
Frequency of painful procedures, analgesia practices and related factors in neonates across neonatal intensive care units of ...
Cruz, Maria Dulce   +2 more
core  

Providing immediate neonatal care and resuscitation at birth beside the mother: clinicians' views, a qualitative study [PDF]

open access: yes, 2015
Objectives: The aims of this study were to assess clinicians’ views and experiences of providing immediate neonatal care at birth beside the mother, and of using a mobile trolley designed to facilitate this bedside care.
Arnold   +20 more
core   +2 more sources

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

open access: yesAdvanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang   +9 more
wiley   +1 more source

Demographic Analysis of Birthweight-Specific Neonatal Mortality [PDF]

open access: yes
This paper explores the determinants of birthweight-specific neonatal mortality rates across States in the U.S. in 1980. We are able to explore the interactions between the determinants and birthweight because of the new data available through the ...
Hope Corman   +2 more
core  

Pola Bakteri Aerob Penyebab Infeksi Nosokomial Pada Ruangan Neonatal Intensive Care Unit (Nicu) Blu Rsup Prof. Dr. R. D Kandou Manado [PDF]

open access: yes, 2015
: Nosocomial infection is an infection which occurs in the hospital caused by microbacteria from the hospital. Infection in neonatal is a serious issue in each hospital until today. Neonatal Intensive Care Unit (NICU) is a care unit for newborn who needs
Rares, F. E. (Fredine)   +2 more
core  

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