Results 91 to 100 of about 7,511,780 (403)
Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit.
Journal of the American Medical Association (JAMA), 2004 CONTEXT In the intensive care unit (ICU), delirium is a common yet underdiagnosed form of organ dysfunction, and its contribution to patient outcomes is unclear.
E. Ely +8 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
wiley +1 more source
The health and social consequences of an alcohol related admission to critical care: a qualitative study [PDF]
, 2016 Objective: To examine the impact of critical care on future alcohol-related behaviour. Further, it aimed to explore patterns of recovery for patients with and without alcohol use disorders beyond the hospital environment.
Forrest, Ewan +4 more
core +1 more source
Artificial intelligence in the intensive care unit
Critical Care, 2019 The use of artificial intelligence (AI) in healthcare is receiving increasing interest, driven by a surge in scientific research and funding. AI has shown ophthalmologist-level performance at detecting retinal pathology [1] and can provide individualised
C. Lovejoy, V. Buch, M. Maruthappu
semanticscholar +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Long-term cognitive outcomes among unselected ventilated and non-ventilated ICU patients
Journal of Intensive Care, 2017 Background Cognitive dysfunction is an important long-term complication of critical illness associated with reduced quality of life, increase in healthcare costs, and institutionalization.
José Raimundo A. de Azevedo +8 more
doaj +1 more source
Preparing intensive care for the next pandemic influenza
Critical Care, 2019 Few viruses have shaped the course of human history more than influenza viruses. A century since the 1918–1919 Spanish influenza pandemic—the largest and deadliest influenza pandemic in recorded history—we have learned much about pandemic influenza and ...
Taylor Kain, R. Fowler
semanticscholar +1 more source
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis
Intensive Care Medicine, 2017 PurposeFunctional status and chronic health status are important baseline characteristics of critically ill patients. The assessment of frailty on admission to the intensive care unit (ICU) may provide objective, prognostic information on baseline health.
J. Muscedere +8 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source