Results 91 to 100 of about 7,689,168 (361)

A Subtle Presentation of Pharyngitis and Pneumonia: Lemierre Syndrome

Case Reports in Pulmonology
Lemierre syndrome (LS) is a rare condition with an estimated incidence of 1–10/1,000,000 per year defined as a complication of an oral and nasopharyngeal infection with secondary septicemia leading to septic emboli and internal jugular vein thrombosis ...
Federico Bellini, Valentino Allocca, Laura Aspidistria, Marco Farinatti, Ippolito Guzzinati, Marta Maria Daniele, Serena Casanova, Francesca Gasparini, Mara Nalin, Sara Saturni, Gian Luca Casoni   +10 more
doaj   +1 more source

Long-term cognitive outcomes among unselected ventilated and non-ventilated ICU patients

Journal of Intensive Care, 2017
Background Cognitive dysfunction is an important long-term complication of critical illness associated with reduced quality of life, increase in healthcare costs, and institutionalization.
José Raimundo A. de Azevedo, Widlani Sousa Montenegro, Djane Pereira Rodrigues, Suellen C. de C. Souza, Vanessa F. S. Araujo, Margareth Pereira de Paula, Patricia H. C. P. Prazeres, Adenilde da Luz Leitão, Adriana V. N. Mendonça   +8 more
doaj   +1 more source

Benchmarking Intensive Care Physiotherapy Staffing in Australian Tertiary Hospitals [PDF]

, 2008
Physiotherapy is an important component in the management of patients in the Intensive Care Unit (ICU). Existing guidelines on ICU physiotherapy staffing represent European settings and are not contemporary. With no specific recommendations in Australia,
Patman, Shane, Sun, Wenxing
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Esophageal Achalasia: An Unusual Cause of Respiratory Distress

Case Reports in Critical Care
Esophageal achalasia is a rare condition affecting both men and women. It is a motility disorder of the esophagus resulting in the lack of relaxation of the lower sphincter, yielding to food stasis.
Océane Thiry, Marion Schaefer, Aurélie Cravoisy, Lionel Nace, Thibault François, Jacques Allard, Sébastien Gibot   +6 more
doaj   +1 more source

Parents’ and carers’ experiences of transition and aftercare following a child's discharge from a paediatric intensive care unit to an in-patient ward setting:A qualitative systematic review [PDF]

, 2019
Objectives: To explore parents’ experiences of transition and aftercare following their child’s discharge from a pediatric intensive care unit to an inpatient ward.Methods: A qualitative systematic review was conducted.
Evans, Catrin, Manning, Joseph C., Suleman, Zainab   +2 more
core   +2 more sources

The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis

Intensive Care Medicine, 2017
PurposeFunctional status and chronic health status are important baseline characteristics of critically ill patients. The assessment of frailty on admission to the intensive care unit (ICU) may provide objective, prognostic information on baseline health.
J. Muscedere, J. Muscedere, Braden Waters, Aditya Varambally, S. Bagshaw, J. Boyd, D. Maslove, S. Sibley, K. Rockwood   +8 more
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Preparing intensive care for the next pandemic influenza

Critical Care, 2019
Few viruses have shaped the course of human history more than influenza viruses. A century since the 1918–1919 Spanish influenza pandemic—the largest and deadliest influenza pandemic in recorded history—we have learned much about pandemic influenza and ...
Taylor Kain, R. Fowler
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source