Results 111 to 120 of about 5,614,983 (259)

Optimal productive size of hospital’s intensive care units [PDF]

Hospital, Intensive Care Units, Returns to Scale, Optimal ...
James Moises, Vivian Valdmanis, Hervé Leleu   +2 more
core  

Prognosis of Patients Transferred From Intensive Care Units to Departments of Chest Diseases and the Factors Affecting Their Prognosis

, 2011
Aim: One-third of deaths due to a critical disease occur after patients are transferred from intensive care units to hospital departments. Some of the deaths occur in patients who are considered not to need further intensive care treatment or that they ...
Serdar Kalemci, Can Sevinc, Hulya Ellidokuz, ELLİDOKUZ, HÜLYA, Kalemci, Serdar, SEVİNÇ, CAN   +5 more
core   +1 more source

Knowledge, Attitude, and Practice of Thrombolysis in Family Members of Cerebral Infarction Patients: Structural Equation Modeling Analysis

International Journal of General Medicine
Fan Huang,1,2 Ling Zhou,1,2 Ping Zhao,1,2 Meiping Guo,1,2 Wujia Chen1,2 1Intensive Care Unit, Wujin Hospital Affiliated with Jiangsu University, Changzhou, 213000, People’s Republic of China; 2The Wujin Clinical College of Xuzhou Medical University ...
Huang F, Zhou L, Zhao P, Guo M, Chen W
doaj  

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Intensive Care Unit Infections and Antibiotic Use

, 2011
Burn wound infections is the leading cause of morbidity and mortality in burn trauma patients. Although burn wound is sterile at the beginning, because of risk factors such as prolonged hospital stay, immunesuppression and burn affecting large body ...
Ayşegül Yeşilkaya, Hande Arslan
core  

Effects of HALP Score, C-Reactive Protein/Albumin Ratio, and Platelet/Lymphocyte Ratio on Predicting Mortality in Geriatric Patients in the Respiratory Intensive Care Unit

Clinical Interventions in Aging
Kamuran Uluç,1 Esra Akkütük Öngel,2 Şükran Merve Çolakoğlu,2 Nazan Köylü İlkaya,2 Özkan Devran,2 Ahmet Oğuzhan Küçük,3 Hatice Kutbay Özçelik2 1Department of Critical Care Medicine, University of Health Sciences ...
Uluç K, Akkütük Öngel E, Çolakoğlu ŞM, Köylü İlkaya N, Devran Ö, Küçük AO, Kutbay Özçelik H   +6 more
doaj  

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Multivariate Analysis of Shock Risk and Model Development and Validation in Elderly Patients Following Hip Fracture Surgery in the Intensive Care Unit (ICU): A Retrospective Cohort Study

Clinical Interventions in Aging
Xue Wang, Zhen Cui, Mengqi Tong, Miaomiao Yu, Ying Bai Department of Critical Care Medicine, Beijing Jishuitan Hospital Affiliated to Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Ying Bai, Department of ...
Wang X, Cui Z, Tong M, Yu M, Bai Y
doaj  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source