Results 101 to 110 of about 2,458,151 (310)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Successful Management of Extreme Hyperglycemia (134 mmol/L) Secondary to Chronic Pancreatitis Causing Critical Hyperosmolar Coma: A Case Report

Case Reports in Endocrinology
Hyperosmolar hyperglycemic state (HHS) is a life-threatening condition characterized by extreme hyperglycemia, high plasma osmolality, and severe dehydration without significant ketoacidosis.
Arnaud Robert, Sandra Ihirwe Habineza, David Leng, Chloé Dieudonné, Patrick M. Honoré, Pierre Bulpa   +5 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Integration of Diaphragmatic Ultrasonography and Intra-Abdominal Pressure Measurement for Optimizing Weaning from Mechanical Ventilation

Risk Management and Healthcare Policy
Dan Su,1,* Ruixin Li,1,* Zhi Chen,2 Na Cui,1 Zhanbiao Yu,1 Xiaoxu Ding,1 Jiaqian Wu1 1Intensive Care Unit, The Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, People’s Republic of China; 2Department of ...
Su D, Li R, Chen Z, Cui N, Yu Z, Ding X, Wu J   +6 more
doaj  

Evaluation of One-Year Survival and Quality of Life After Intensive Care: A Retrospective 5-Year Study

International Journal of Clinical Practice
Conclusion: The findings indicate that approximately one-quarter of patients treated in intensive care and discharged from the hospital died within 1 year.
Recep Civan Yüksel, Birkan Ülger, Kamil Deveci, Şahin Temel, Murat Sungur, Kürşat Gündoğan   +5 more
doaj   +1 more source

Intensive care unit discharge to the ward with a tracheostomy cannula as a risk factor for mortality: A prospective, multicenter propensity analysis [PDF]

, 2011
To analyze the impact of decannulation before intensive care unit discharge on ward survival in nonexperimental conditions. DESIGN: Prospective, observational survey.
Fernandez, R. (Rafael), Frutos, F. (Fernando), Garcia-Sanchez, M. (Manuela), Gomez, M.J. (María Jesús), Gonzalez, J. (Javier), Hernandez, G. (Gonzalo), Ibañez, P. (Pedro), Marcos, A. (Alfredo), Monedero, P. (Pablo), Tizon, A.I. (Ana Isabel), Torre, M.V. (María Victoria) de la   +10 more
core  

Intensive care transfers.

Critical care (London, England), 2002
The demand for intensive care has increased relentlessly over the past 30 years. It is now regarded as a necessity rather than a luxury. The provision of intensive care has lagged behind that demand. Thus, patients who are judged to need intensive care when a bed is unavailable are increasingly transferred to another hospital for such care. The present
Hopkins, Philip, Wolff, Anthony H
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

COVID-19 related acute necrotizing encephalopathy and acute myocarditis in an adult female: a novel case report of brain injury and myocarditis

BMC Neurology
Background Acute necrotizing encephalopathy (ANE) and myocarditis are both acute, life-threatening conditions that can be triggered by COVID-19. We report a case of sequential ANE and myocarditis following a COVID-19 infection.
Chang Xu, Yuyi Sha, Jianneng Pan, Tao Pan, Xiaoyang Zhou, Hua Wang, Zhaojun Xu, Bixin Chen   +7 more
doaj   +1 more source

Intensive care [PDF]

BMJ, 2007
openaire   +2 more sources