Results 91 to 100 of about 5,614,983 (259)

Successful Management of Extreme Hyperglycemia (134 mmol/L) Secondary to Chronic Pancreatitis Causing Critical Hyperosmolar Coma: A Case Report

open access: yesCase Reports in Endocrinology
Hyperosmolar hyperglycemic state (HHS) is a life-threatening condition characterized by extreme hyperglycemia, high plasma osmolality, and severe dehydration without significant ketoacidosis.
Arnaud Robert   +5 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Melatonin Suppresses NLRP3 Inflammasome Activation via SIRT1-Mediated ETS1 Deacetylation to Attenuate LPS-Induced Pyroptosis in Alveolar Epithelial Cells

open access: yesJournal of Inflammation Research
Fan He, Chunzi Liu, Yun Yu, Qiaofang Wang, Lin Li, Xiaoyun Chao, Liping Chen, Cong Yu Neonatal Intensive Care Unit, Jiangxi Provincial Children’s Hospital, Nanchang, Jiangxi, 330038, People’s Republic of ChinaCorrespondence: Liping Chen, Neonatal ...
He F   +7 more
doaj  

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

open access: yesFEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson   +2 more
wiley   +1 more source

The Effect of Care Bundles Based on Guidelines Over the Central Venous Catheter Infections in an Intensive Care Unit

open access: yes, 2014
Objective: To detect the effects of care bundle that is prepared depending on guidelines for central line associated infections. Material and Method: Patients in a tertiary medical intensive care unit were followed up during one year period in terms of ...
Fatma Ülger   +7 more
core   +1 more source

Comparative Prognostic Performance of SOFA2.0 and SOFA for 28-Day Mortality in Patients Developing Sepsis During ECMO Support

open access: yesJournal of Inflammation Research
Jia-Yi Chen,1,2,* Xiao-Ling Gu,3,* Hai-Yan Liu,4 Tong Li,5 Yong-Wei Yu,5 Mi Xu51Intensive Care Unit, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang, 310000, People’s Republic of ...
Chen JY   +5 more
doaj  

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

open access: yesFEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan   +11 more
wiley   +1 more source

UCH-L1 Inhibitor Alleviates Nerve Damage Caused by Moyamoya Disease

open access: yesApplied Bionics and Biomechanics
Background. Moyamoya disease (MMD) leads to nerve injury. Exosomes are touted as bio-shuttles for the delivery of distinct biomolecules inside the cells. Recently, UCH-L1 was shown to play a vital role in nerve injury.
Minghua Xu   +10 more
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

open access: yesFEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph   +7 more
wiley   +1 more source

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