Results 131 to 140 of about 6,043,824 (343)

Higher Atherogenic Index of Plasma Is Associated with Hyperuricemia: A National Longitudinal Study

International Journal of Endocrinology
Background. The association between atherogenic index of plasma (AIP) and hyperuricemia remains indistinct. This study was aimed to examine the relationship between AIP and hyperuricemia among the middle-aged and the elderly Chinese population.
Feifei Xu, Chengyong Ma, Shouping Wang, Qin Li, Zhongwei Zhang, Min He   +5 more
doaj   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

A Bibliometric Analysis of Medication Compliance in Children with Asthma

Journal of Multidisciplinary Healthcare
Jing Zhao,1 Yu Ding,1 Zhiyuan Wang,2 Guo Kou,1 Sen Xu,1 Jing Tai,1 Chunrui Zhang,1 Ying Guo,1 Jun Yang1 1Department of Pediatric Intensive Care, Nanyang Second People’s Hospital, Nanyang, Henan, 473012, People’s Republic of China; 2Department of ...
Zhao J, Ding Y, Wang Z, Kou G, Xu S, Tai J, Zhang C, Guo Y, Yang J   +8 more
doaj  

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Intensive care in Spain

Revista Española de Anestesiología y Reanimación (English Edition), 2020
C.A. Sánchez Pérez, R. Peyró García, Pablo Monedero, F. Barturen, M. Heredia Rodríguez, M Varela Durán, O.M. Padrón Ruiz, V. Torres Pedrós, L. Fernández-Quero Bonilla, F. García-Montoto Pérez, E. Tamayo Gómez, R. González Celdrán, A. Pérez Carbonell, C. López Sánchez, J. Cardona Peretó, R. Cabadas Avión, D. Paz-Martín, C. Soria Gulina, N. Ojeda Betancor, C. Ferrando Ortolá   +19 more
openaire   +6 more sources

ESPEN guideline on clinical nutrition in the intensive care unit.

Clinical Nutrition, 2019
P. Singer, A. Blaser, M. Berger, W. Alhazzani, P. Calder, M. Casaer, M. Hiesmayr, K. Mayer, J. Montejo, C. Pichard, J. Preiser, A. V. van Zanten, Simon J Oczkowski, W. Szczeklik, S. Bischoff   +14 more
semanticscholar   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit

Critical Care Medicine, 2013
J. Barr, Gilles L. Fraser, K. Puntillo, E. Ely, C. Gélinas, Joseph F. Dasta, Judy E. Davidson, John W. Devlin, John P. Kress, Aaron M. Joffe, D. Coursin, Daniel L. Herr, A. Tung, Bryce R. H. Robinson, Dorrie K. Fontaine, Michael A. Ramsay, R. Riker, C. Sessler, B. Pun, Y. Skrobik, Roman Jaeschke   +20 more
semanticscholar   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source