Results 81 to 90 of about 6,043,824 (343)

Co-Occurrence of Post-Intensive Care Syndrome Problems Among 406 Survivors of Critical Illness*

Critical Care Medicine, 2018
Objectives: To describe the frequency of co-occurring newly acquired cognitive impairment, disability in activities of daily livings, and depression among survivors of a critical illness and to evaluate predictors of being free of post-intensive care ...
A. Marra, P. Pandharipande, T. Girard, Mayur B. Patel, C. Hughes, J. Jackson, Jennifer L. Thompson, R. Chandrasekhar, E. W. Ely, N. Brummel   +9 more
semanticscholar   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

A Subtle Presentation of Pharyngitis and Pneumonia: Lemierre Syndrome

Case Reports in Pulmonology
Lemierre syndrome (LS) is a rare condition with an estimated incidence of 1–10/1,000,000 per year defined as a complication of an oral and nasopharyngeal infection with secondary septicemia leading to septic emboli and internal jugular vein thrombosis ...
Federico Bellini, Valentino Allocca, Laura Aspidistria, Marco Farinatti, Ippolito Guzzinati, Marta Maria Daniele, Serena Casanova, Francesca Gasparini, Mara Nalin, Sara Saturni, Gian Luca Casoni   +10 more
doaj   +1 more source

Nephrogenic Diabetes Insipidus following an Off-Label Administration of Sevoflurane for Prolonged Sedation in a COVID-19 Patient and Possible Influence on Aquaporin-2 Renal Expression

Case Reports in Anesthesiology, 2022
During the recent COVID-19 pandemic, the rapidly progressive shortage of intravenous sedative drugs led numerous intensive care units to look for potential alternatives in patients requiring mechanical ventilation for severe acute respiratory distress ...
Camie Dupuis, Arnaud Robert, Ludovic Gerard, Johann Morelle, Pierre-François Laterre, Philippe Hantson   +5 more
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit.

Journal of the American Medical Association (JAMA), 2004
CONTEXT In the intensive care unit (ICU), delirium is a common yet underdiagnosed form of organ dysfunction, and its contribution to patient outcomes is unclear.
E. Ely, A. Shintani, B. Truman, T. Speroff, S. Gordon, F. Harrell, S. Inouye, G. Bernard, R. Dittus   +8 more
semanticscholar   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Esophageal Achalasia: An Unusual Cause of Respiratory Distress

Case Reports in Critical Care
Esophageal achalasia is a rare condition affecting both men and women. It is a motility disorder of the esophagus resulting in the lack of relaxation of the lower sphincter, yielding to food stasis.
Océane Thiry, Marion Schaefer, Aurélie Cravoisy, Lionel Nace, Thibault François, Jacques Allard, Sébastien Gibot   +6 more
doaj   +1 more source

Artificial intelligence in the intensive care unit

Critical Care, 2019
The use of artificial intelligence (AI) in healthcare is receiving increasing interest, driven by a surge in scientific research and funding. AI has shown ophthalmologist-level performance at detecting retinal pathology [1] and can provide individualised
C. Lovejoy, V. Buch, M. Maruthappu
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source