Results 41 to 50 of about 1,303,394 (303)

Biomarker profiles of coagulopathy and alveolar epithelial injury in acute respiratory distress syndrome with idiopathic/immune-related disease or common direct risk factors

Critical Care, 2019
Background Altered coagulation and alveolar injury are the hallmarks of acute respiratory distress syndrome (ARDS). However, whether the biomarkers that reflect pathophysiology differ depending on the etiology of ARDS has not been examined.
Kansuke Koyama, Shinshu Katayama, Ken Tonai, Jun Shima, Toshitaka Koinuma, Shin Nunomiya   +5 more
doaj   +1 more source

Prophylactic noninvasive respiratory support in the immediate postoperative period after cardiac surgery - a systematic review and network meta-analysis

BMC Pulmonary Medicine, 2023
Background Noninvasive respiratory support has been increasingly applied in the immediate postoperative period to prevent postoperative pulmonary complications (PPCs). However, the optimal approach remains uncertain. We sought to evaluate the comparative
Xiaoyang Zhou, Jianneng Pan, Hua Wang, Zhaojun Xu, Long Zhao, Bixin Chen   +5 more
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Transient hyperlactatemia during intravenous administration of glycerol: a prospective observational study

Journal of Intensive Care, 2018
Background Intravenous glycerol treatment, usually administered in the form of a 5% fructose solution, can be used to reduce intracranial pressure.
Shinshu Katayama, Ken Tonai, Yuya Goto, Kansuke Koyama, Toshitaka Koinuma, Jun Shima, Masahiko Wada, Shin Nunomiya   +7 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Markers of acute kidney injury in patients with sepsis: the role of soluble thrombomodulin

Critical Care, 2017
Background Endothelial activation and damage occur early during sepsis, with activated coagulopathy and playing a major role in the pathophysiology of sepsis-induced acute kidney injury (AKI).
Shinshu Katayama, Shin Nunomiya, Kansuke Koyama, Masahiko Wada, Toshitaka Koinuma, Yuya Goto, Ken Tonai, Jun Shima   +7 more
doaj   +1 more source

The use of automated pupillometry to assess cerebral autoregulation: a retrospective study

Journal of Intensive Care, 2020
Background Critically ill patients are at high risk of developing neurological complications. Among all the potential aetiologies, brain hypoperfusion has been advocated as one of the potential mechanisms.
Armin Quispe Cornejo, Carla Sofía Fernandes Vilarinho, Ilaria Alice Crippa, Lorenzo Peluso, Lorenzo Calabrò, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone   +7 more
doaj   +1 more source

Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’

Critical Care, 2019
BackgroundBeta-lactam antibiotics (βLA) are the most commonly used antibiotics in the intensive care unit (ICU). ICU patients present many pathophysiological features that cause pharmacokinetic (PK) and pharmacodynamic (PD) specificities, leading to the ...
R. Guilhaumou, S. Benaboud, Y. Bennis, C. Dahyot-Fizelier, E. Dailly, P. Gandia, S. Goutelle, S. Lefeuvre, N. Mongardon, C. Roger, J. Scala-Bertola, F. Lemaitre, M. Garnier   +12 more
semanticscholar   +1 more source

Carbon monoxide in intensive care medicine—time to start the therapeutic application?!

Intensive Care Medicine Experimental, 2020
Carbon monoxide (CO) is not only known as a toxic gas due to its characteristics as an odorless molecule and its rapid binding to haem-containing molecules, thus inhibiting the respiratory chain in cells resulting in hypoxia.
U. Goebel, Jakob Wollborn
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source