Results 61 to 70 of about 707,244 (301)

Development and evaluation of the focused assessment of sonographic pathologies in the intensive care unit (FASP-ICU) protocol

, 2023
Background The use of ultrasonography in the intensive care unit (ICU) is steadily increasing but is usually restricted to examinations of single organs or organ systems.
Quintel, Michael, Schmidt, Stefan, Dieks, Jana-Katharina, Moerer, Onnen, Schmidt, Stefan; Department of Anesthesiology, Emergency and Intensive Care Medicine, University Hospital Goettingen, Georg August University, Goettingen, Germany, Quintel, Michael; Department of Anesthesiology, Emergency and Intensive Care Medicine, University Hospital Goettingen, Georg August University, Goettingen, Germany, Moerer, Onnen; Department of Anesthesiology, Emergency and Intensive Care Medicine, University Hospital Goettingen, Georg August University, Goettingen, Germany, Dieks, Jana-Katharina; Department of Pediatric Cardiology and Pediatric Intensive Care Medicine, University Hospital Goettingen, Georg August University, Goettingen, Germany   +7 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Randomised trials of 6 % tetrastarch (hydroxyethyl starch 130/0.4 or 0.42) for severe sepsis reporting mortality: systematic review and meta-analysis [PDF]

, 2013
14.03.13 KB. Ok to add accepted version to spiral. SpringerPurpose To assess the impact of 6 % tetrastarch [hydroxyethyl starch (HES) 130/0.4 and 130/0.42] in severe sepsis patients. The primary outcome measure was 90-day mortality.
Waheed, U, Brett, SJ, Patel, A
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

International standards for programmes of training in intensive care medicine in Europe [PDF]

, 2010
PURPOSE To develop internationally harmonised standards for programmes of training in intensive care medicine (ICM). METHODS Standards were developed by using consensus techniques.
The CoBaTrICE Collaboration, Wilde, J.D., Rothen, Hans Ulrich, null null, Bullock, A., Girbes, A.R.J., van Mook, Walther, Bullock, Alison Deborah, Wilde, J. D., Bion, J.K., Bion, J.F.   +10 more
core   +1 more source

We wish you a smooth takeoff! Launching “Intensive Care Fundamentals”: an ESICM educational initiative for newcomers to intensive care unit

, 2022
Only a few of us will ever forget that overwhelming feeling when we entered the intensive care unit (ICU) for the very first time as young doctors. Every year, more and more doctors come to the ICU for the first time, either at the start of their career ...
Cecconi, Maurizio, Intensive Care Fundamentals Taskforce Members of the European Society of Intensive Care Medicine (ESICM), Duska, Frantisek   +2 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Higher Atherogenic Index of Plasma Is Associated with Hyperuricemia: A National Longitudinal Study

International Journal of Endocrinology
Background. The association between atherogenic index of plasma (AIP) and hyperuricemia remains indistinct. This study was aimed to examine the relationship between AIP and hyperuricemia among the middle-aged and the elderly Chinese population.
Feifei Xu, Chengyong Ma, Shouping Wang, Qin Li, Zhongwei Zhang, Min He   +5 more
doaj   +1 more source

Determining the Difficulties of Parents with Children in Home Care Who Were Discharged from Intensive Care [PDF]

Introduction: This study was performed to determine the difficulties experienced by parents with children in home care who were discharged from intensive care.
Gülzade Uysal, Atiye Karakul, Duygu Sönmez Düzkaya, Gülçin Bozkurt, Tülay Yakut   +4 more
core   +1 more source