Results 71 to 80 of about 707,244 (301)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Predicting the occurrence of multidrug-resistant organism colonization or infection in ICU patients: development and validation of a novel multivariate prediction model

Antimicrobial Resistance and Infection Control, 2020
Background Multidrug-resistant organisms (MDROs) have emerged as an important cause of poor prognoses of patients in the intensive care unit (ICU). This study aimed to establish an easy-to-use nomogram for predicting the occurrence of MDRO colonization ...
Li Wang, Xiaolong Huang, Jiating Zhou, Yajing Wang, Weizhang Zhong, Qing Yu, Weiping Wang, Zhiqiao Ye, Qiaoyan Lin, Xing Hong, Ping Zeng, Minwei Zhang   +11 more
doaj   +1 more source

The impact of lung ultrasound on clinical-decision making across departments: a systematic review

The Ultrasound Journal, 2022
Background Lung ultrasound has established itself as an accurate diagnostic tool in different clinical settings. However, its effects on clinical-decision making are insufficiently described.
Micah L. A. Heldeweg, Lian Vermue, Max Kant, Michelle Brouwer, Armand R. J. Girbes, Mark E. Haaksma, Leo M. A. Heunks, Amne Mousa, Jasper M. Smit, Thomas W. Smits, Frederique Paulus, Johannes C. F. Ket, Marcus J. Schultz, Pieter Roel Tuinman   +13 more
doaj   +1 more source

Investigation of Species Distribution and Antifungal Susceptibility of Candida Species Isolated from Various Clinical Samples From Intensive Care Unit Patients

, 2016
Objective: Infections caused by Candida species are becoming important causes of morbidity and mortality in intensive care patients. The aim of this study was to determine species distribution and antifungal susceptibility of 121 Candida species isolated
Pelit, Suleyman, Uzun, Meltem
core   +1 more source

Serum Lactate as an Independent Predictor of In-Hospital Mortality in Intensive Care Patients [PDF]

, 2020
Purpose: The aim of this study was to check if serum lactate was independently associated with mortality among critically ill patients. Materials and Methods: This was a single-center, retrospective cohort study. All adult patients (>18 years of age) who
Sadat, Musharaf, Bou Chebl, Ralph, Abou Dagher, Gilbert, Tamim, Hani Mohammed, Enezi, Farhan Al, Arabi, Yaseen M.   +5 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Adsorption therapy in critically ill with septic shock and acute kidney injury: a retrospective and prospective cohort study

Annals of Intensive Care, 2020
Background Haemoadsorption has been described as an effective way to control increased pro- and anti-inflammatory mediators (“cytokine storm”) in septic shock patients. No prospective or randomised clinical study has yet confirmed these results. However,
Gregor A. Schittek, Philipp Zoidl, Michael Eichinger, Simon Orlob, Holger Simonis, Martin Rief, Philipp Metnitz, Tobias Fellinger, Jens Soukup   +8 more
doaj   +1 more source

Early Diagnosis, Care, and Discharge Education of Patients with Acute Pancreatitis by the Intensive Care Team

, 2015
WOS: 000422391400006Acute pancreatitis can be the primary cause of hospitalization in intensive care units, while it can also develop as a result of a complication of an illness.
Topbas, Eylem
core   +1 more source

Year in review in Intensive Care Medicine 2012. II: Pneumonia and infection, sepsis, coagulation, hemodynamics, cardiovascular and microcirculation, critical care organization, imaging, ethics and legal issues [PDF]

, 2013
Non
Rocco, P, Jan Wernerman, Preiser, Jean-Charles, Mancebo, J, Timsit, JF, Salvatore M. Maggiore, Mancebo, Jordi, Maggiore, Salvatore M, Mebazaa, A, Jordi Mancebo, Curtis, JR, Bonten, M, Marc Bonten, Conti, G, Macrae, D, Antonelli, M, Zhang, H., Curtis, Randall J.R., Maggiore, Salvatore Maurizio, Rocco, Patricia, Chastre, J, Maggiore, Salvatore M., Preiser, JC, Giorgio Conti, Chastre, Jean, Giuseppe Citerio, Citerio, Giuseppe, Goran Hedenstierna, Mebazaa, Alexandre, Maggiore, SM, Antonelli, Massimo, Joannidis, Michael, Massimo Antonelli, Timsit, Jean François, Jean Chastre, Wernerman, J, Maurizio Cecconi, J. Randall Curtis, Hedenstierna, Goran, Timsit, Jean-François, Joannidis, M, Haibo Zhang, Citerio, G, Jean-François Timsit, Jean-Charles Preiser, MacRae, Duncan, Alexandre Mebazaa, Michael Joannidis, Preiser, Jean Charles, Hedenstierna, Göran,, Conti, Giorgio, Cecconi, M, Hedenstierna, G, Wernerman, Jan, Bonten, Marc, Cecconi, Maurizio, Patricia Rocco, Maggiore, Salvatore, Curtis, J.Randall, Universitat Autònoma de Barcelona, Zhang, H, Zhang, Haibo, Duncan Macrae, Curtis, J Randall   +63 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source