Results 71 to 80 of about 7,575,842 (291)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo-controlled trial

, 2017
Purpose: The aim of the INSTINCT trial was to assess the effect of intravenous polyspecific immunoglobulin G (IVIG) compared with placebo on self-reported physical function in intensive care unit (ICU) patients with necrotising soft tissue infection ...
Madsen, Martin B., Lange, Theis, Norrby-Teglund, Anna, Anna Norrby-Teglund, Hjortrup, PB, Hjortrup, Peter B., Lange, T, Hansen, MB, Marco B. Hansen, Ole Hyldegaard, Theis Lange, Hyldegaard, O, Hyldegaard, Ole, Perner, Anders, Anders Perner, Madsen, MB, Perner, A, Martin B. Madsen, Peter B. Hjortrup, Norrby-Teglund, A,, Hansen, Marco B.   +20 more
core   +1 more source

Selective decontamination of the digestive tract in critically ill patients treated in intensive care units: a mixed-methods feasibility study (the SuDDICU study) [PDF]

, 2014
Background: Hospital-acquired infections (HAIs) are a major cause of morbidity and mortality. Critically ill patients in intensive care units (ICUs) are particularly susceptible to these infections.
Rowan, K. M., Martin P Eccles, Stephan U Dombrowski, Rose, L., Brian H Cuthbertson, Prior, Maria E, Jill J Francis, Kathryn M Rowan, Rowan, Kathryn M, Dombrowski, S. U., MacLennan, Graeme, Eccles, Martin P, Campbell, Marion K, H Cuthbertson, Brian, Rob Shulman, Eccles, M. P., Francis, J., Louise Rose, Cuthbertson, B. H., M Duncan, Eilidh, Dombrowski, Stephan U, Duncan, E. M., Cuthbertson, Brian H, P Eccles, Martin, Campbell, Marion Kay, Geoff Bellingan, Prior, M. E., Prior, Maria Elizabeth, Maria E Prior, Wilson, A. P. R., Dombrowski, Stephan Ulrich, A Peter R Wilson, Francis, Jill J, Bellingan, Geoff, J Francis, Jill, Duncan, Eilidh M, Shulman, Rob, Rose, Louise, S Maclennan, Graeme, Peter R Wilson, A, Eilidh M Duncan, Shulman, R., Campbell, M. K., M Rowan, Kathryn, Graeme S MacLennan, Wilson, A Peter R, Bellingan, G., Marion K Campbell, MacLennan, G.   +48 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Sudden Onset of Coma and Fulminant Progression to Brain Death in a 48-Year-Old Male With Cerebral Malaria

Case Reports in Critical Care
Cerebral malaria is the most severe complication of Plasmodium falciparum infection. Left untreated, it is universally fatal. Coma is the clinical hallmark, emerging between the first and third days of fever.
Marina Costa, Cristiana Barbosa, Mauro Pereira, Luís Ribeiro, Pedro Silveira   +4 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The focal index: a quantitative approach to morphological sub-phenotyping of COVID-19 patients with acute respiratory distress syndrome: a pilot study

Intensive Care Medicine Experimental
Background Acute respiratory distress syndrome (ARDS) is characterised by significant morphological heterogeneity. Morphological sub-phenotyping can potentially be used to personalise mechanical ventilation.
Kristin Jona Bjarnadottir, Martin Tovedal, Gaetano Perchiazzi, Miklos Lipcsey, Lucian Covaciu, Magnus von Seth, Rafael Kawati, Mariangela Pellegrini   +7 more
doaj   +1 more source

Predicting the occurrence of multidrug-resistant organism colonization or infection in ICU patients: development and validation of a novel multivariate prediction model

Antimicrobial Resistance and Infection Control, 2020
Background Multidrug-resistant organisms (MDROs) have emerged as an important cause of poor prognoses of patients in the intensive care unit (ICU). This study aimed to establish an easy-to-use nomogram for predicting the occurrence of MDRO colonization ...
Li Wang, Xiaolong Huang, Jiating Zhou, Yajing Wang, Weizhang Zhong, Qing Yu, Weiping Wang, Zhiqiao Ye, Qiaoyan Lin, Xing Hong, Ping Zeng, Minwei Zhang   +11 more
doaj   +1 more source