Results 91 to 100 of about 707,244 (301)

Identifying Priorities in Intensive Care : a description of a system for collecting intensive care data, an analysis of the data collected, a critique of aspects of severity scoring systems used to compare intensive care outcome, identification of priorities in intensive care and proposals to improve outcome for intensive care patients.

, 1999
MDThis thesis reviews the requirements for intensive care audit data and describes the development of ICARUS (Intensive Care Audit and Resource Utilisation System), a system to collect and analyse intensive care audit information.
Goldhill, David Raymond
core  

The Concept of Ethics in the Intensive Care

, 2010
The concept of ethics in the intensive care unit has developed in the last 50 years along with the advancements and regulations in this area of medicine.
Kutay Alpir
core   +1 more source

Addressing gender imbalance in intensive care

, 2021
There is a large gender gap in critical care medicine with women underrepresented, particularly in positions of leadership. Yet gender diversity better reflects the current critical care community and has multiple beneficial effects at individual and ...
Rubulotta, Francesca, Juffermans, Nicole Petra, Burns, Karen K.E.A., Juffermans, Nicole P., Juffermans, Nicole P, Burns, Karen E A, Pourzitaki, Chryssa, Ranieri, Marco V.M., Burns, Karen E. A., Ranieri, V. M, Vincent, Jean-Louis, Vincent, Jean Louis, Ranieri, V. Marco   +12 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Burden, risk factors, and outcomes respiratory syncytial virus (RSV) infection in pediatric intensive care units in Türkiye (RSVP Study 2020-2024)

BMC Pediatrics
Background Respiratory syncytial virus (RSV) is one of the leading causes of respiratory tract infections in infants and young children requiring a pediatric intensive care unit (PICU).
Yasemin Coban, Gultac Evren, Dincer Yildizdas, Neslihan Zengin, Alkan Bal, Tanıl Kendirli, Merve Havan, Eda Eyduran, Muhterem Duyu, Ayşe Aşık, Nazik Yener, Hatice Elif Kınık Kaya, Muhammed Udurgucu, Eylem Kiral, Gurkan Bozan, Mehmet Arda Kilinc, Nagehan Aslan, Mustafa Colak, Esra Sevketoglu, Seher Erdogan, Hazal Ceren Tugrul, Fatih Akın, Abdullah Akkus, Nihal Akcay, Ilyas Bingol, Oguz Dursun, Nazan Ulgen Tekerek, Alper Koker, Mutlu Uysal Yazıcı, Ebru Azapagasi, Nuri Alacakir, Caglar Odek, Didar Arslan, Faruk Ekinci, Ozden Ozgur Horoz, Ese Eda Turanli, Feyza Incekoy, Nilufer Yalindag Ozturk, Ali Ertug Arslankoylu, Mehmet Alakaya, Merve Misirlioglu, Resul Yilmaz, Ali Korulmaz, Ezgi Ozlem Ozmen, Ener Cagri Dinleyici   +44 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Year in review in Intensive Care Medicine 2012: III. Noninvasive ventilation, monitoring and patient-ventilator interactions, acute respiratory distress syndrome, sedation, paediatrics and miscellanea [PDF]

, 2013
Non
Rocco, P, Jan Wernerman, Preiser, Jean-Charles, Mancebo, J, Timsit, JF, Salvatore M. Maggiore, Mancebo, Jordi, Mebazaa, A, Jordi Mancebo, Timsit, Jean-Francois, Curtis, JR, Bonten, M, Marc Bonten, Conti, G, Macrae, D, Antonelli, M, Curtis, Randall J.R., Maggiore, Salvatore Maurizio, Rocco, Patricia, Chastre, J, Maggiore, Salvatore M., Preiser, JC, Giorgio Conti, Chastre, Jean, Giuseppe Citerio, Rocco, Patricio, Citerio, Giuseppe, Goran Hedenstierna, Mebazaa, Alexandre, Maggiore, SM, Antonelli, Massimo, Joannidis, Michael, Timsit, Jean François, Massimo Antonelli, J. R. Curtis, Jean Chastre, Curtis, J. R., Wernerman, J, Curtis, J.R., Maurizio Cecconi, Hedenstierna, Goran, Joannidis, M, Haibo Zhang, Citerio, G, Jean-François Timsit, Jean-Charles Preiser, MacRae, Duncan, Alexandre Mebazaa, Michael Joannidis, Preiser, Jean Charles, Hedenstierna, Göran,, Conti, Giorgio, Cecconi, M, Hedenstierna, G, Wernerman, Jan, Bonten, Marc, Cecconi, Maurizio, Patricia Rocco, Universitat Autònoma de Barcelona, Zhang, H, Zhang, Haibo, Duncan Macrae   +61 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Prognosis of Patients Transferred From Intensive Care Units to Departments of Chest Diseases and the Factors Affecting Their Prognosis

, 2011
Aim: One-third of deaths due to a critical disease occur after patients are transferred from intensive care units to hospital departments. Some of the deaths occur in patients who are considered not to need further intensive care treatment or that they ...
Serdar Kalemci, Can Sevinc, Hulya Ellidokuz, ELLİDOKUZ, HÜLYA, Kalemci, Serdar, SEVİNÇ, CAN   +5 more
core   +1 more source