Results 81 to 90 of about 1,311,753 (292)

Interprofessional two-man team approach for interhospital transport of ARDS-patients under extracorporeal membrane oxygenation: a 10 years retrospective observational cohort study

BMC Anesthesiology, 2019
Background Extra Corporeal Membrane Oxygenation (ECMO) has become an accepted treatment option for severely ill patients. Due to a limited availability of ECMO support therapy, patients must often be transported to a specialised centre before or after ...
Stefan Felix Ehrentraut, Barbara Schroll, Stefan Lenkeit, Heidi Ehrentraut, Christian Bode, Stefan Kreyer, Florian Kögl, Felix Lehmann, Thomas Muders, Martin Scholz, Claudia Strater, Folkert Steinhagen, Nils Ulrich Theuerkauf, Carsten Weißbrich, Christian Putensen, Jens-Christian Schewe   +15 more
doaj   +1 more source

A central line care maintenance bundle for the prevention of central line–associated bloodstream infection in non–intensive care unit settings [PDF]

, 2016
OBJECTIVE: To evaluate a central line care maintenance bundle to reduce central line-associated bloodstream infection (CLABSI) in non-ICU settings. DESIGN: Before-after trial with 12 month follow-up period.
Ball, Kelly, Fraser, Victoria, Jafarzadeh, S. Reza, Kremer, Pamala, McMullen, Kathleen, O\u27Neil, Caroline, Warren, David, Wood, Helen   +7 more
core   +2 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The focal index: a quantitative approach to morphological sub-phenotyping of COVID-19 patients with acute respiratory distress syndrome: a pilot study

Intensive Care Medicine Experimental
Background Acute respiratory distress syndrome (ARDS) is characterised by significant morphological heterogeneity. Morphological sub-phenotyping can potentially be used to personalise mechanical ventilation.
Kristin Jona Bjarnadottir, Martin Tovedal, Gaetano Perchiazzi, Miklos Lipcsey, Lucian Covaciu, Magnus von Seth, Rafael Kawati, Mariangela Pellegrini   +7 more
doaj   +1 more source

Grid data mining strategies for outcome prediction in distributed intensive care units [PDF]

, 2013
Previous work developed to predict the outcome of patients in the context of intensive care units brought to the light some requirements like the need to deal with distributed data sources. Those data sources can be used to induce local prediction models
Abelha, António, Machado, José Manuel, Miranda, Miguel, Portela, Filipe, Rua, Fernando, Santos, Manuel Filipe, Silva, Álvaro   +6 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Burden, risk factors, and outcomes respiratory syncytial virus (RSV) infection in pediatric intensive care units in Türkiye (RSVP Study 2020-2024)

BMC Pediatrics
Background Respiratory syncytial virus (RSV) is one of the leading causes of respiratory tract infections in infants and young children requiring a pediatric intensive care unit (PICU).
Yasemin Coban, Gultac Evren, Dincer Yildizdas, Neslihan Zengin, Alkan Bal, Tanıl Kendirli, Merve Havan, Eda Eyduran, Muhterem Duyu, Ayşe Aşık, Nazik Yener, Hatice Elif Kınık Kaya, Muhammed Udurgucu, Eylem Kiral, Gurkan Bozan, Mehmet Arda Kilinc, Nagehan Aslan, Mustafa Colak, Esra Sevketoglu, Seher Erdogan, Hazal Ceren Tugrul, Fatih Akın, Abdullah Akkus, Nihal Akcay, Ilyas Bingol, Oguz Dursun, Nazan Ulgen Tekerek, Alper Koker, Mutlu Uysal Yazıcı, Ebru Azapagasi, Nuri Alacakir, Caglar Odek, Didar Arslan, Faruk Ekinci, Ozden Ozgur Horoz, Ese Eda Turanli, Feyza Incekoy, Nilufer Yalindag Ozturk, Ali Ertug Arslankoylu, Mehmet Alakaya, Merve Misirlioglu, Resul Yilmaz, Ali Korulmaz, Ezgi Ozlem Ozmen, Ener Cagri Dinleyici   +44 more
doaj   +1 more source

The acute psychobiological impact of the intensive care experience on relatives. [PDF]

, 2015
There is a growing awareness amongst critical care practitioners that the impact of intensive care medicine extends beyond the patient to include the psychological impact on close family members.
A. Padkin, F.M. Begen, J.M. Turner-Cobb, Johnston M., P. Ramchandani, P.C. Smith   +5 more
core   +2 more sources