Results 81 to 90 of about 8,500,185 (297)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ISTH guidelines for antithrombotic treatment in COVID‐19: Endorsement by the Scandinavian Society of Anaesthesiology and Intensive Care Medicine

, 2023
The Clinical Practice Committee of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine endorses the ISTH guidelines for antithrombotic treatment in COVID-19.
Moller, Morten Hylander,, Marius Rehn, Martin Ingi Sigurðsson, Morten Hylander Møller, Møller, Morten Hylander, Michelle S. Chew, Maija‐Liisa Kalliomäki, Kalliomäki, Maija Liisa, Sigurðsson, Martin Ingi, Olkkola, Klaus T., Kalliomäki, Maija-Liisa, Sigurdsson, Martin Ingi, Chew, Michelle, Kalliomaki, Maija-Liisa,, Klaus T. Olkkola, Chew, Michelle S., Olkkola, Klaus T.,, Rehn, Marius,, Chew, Michelle,, Rehn, Marius, Moller, Morten Hylander, Sigurdsson, Martin Ingi,   +21 more
core   +1 more source

The focal index: a quantitative approach to morphological sub-phenotyping of COVID-19 patients with acute respiratory distress syndrome: a pilot study

Intensive Care Medicine Experimental
Background Acute respiratory distress syndrome (ARDS) is characterised by significant morphological heterogeneity. Morphological sub-phenotyping can potentially be used to personalise mechanical ventilation.
Kristin Jona Bjarnadottir, Martin Tovedal, Gaetano Perchiazzi, Miklos Lipcsey, Lucian Covaciu, Magnus von Seth, Rafael Kawati, Mariangela Pellegrini   +7 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Burden, risk factors, and outcomes respiratory syncytial virus (RSV) infection in pediatric intensive care units in Türkiye (RSVP Study 2020-2024)

BMC Pediatrics
Background Respiratory syncytial virus (RSV) is one of the leading causes of respiratory tract infections in infants and young children requiring a pediatric intensive care unit (PICU).
Yasemin Coban, Gultac Evren, Dincer Yildizdas, Neslihan Zengin, Alkan Bal, Tanıl Kendirli, Merve Havan, Eda Eyduran, Muhterem Duyu, Ayşe Aşık, Nazik Yener, Hatice Elif Kınık Kaya, Muhammed Udurgucu, Eylem Kiral, Gurkan Bozan, Mehmet Arda Kilinc, Nagehan Aslan, Mustafa Colak, Esra Sevketoglu, Seher Erdogan, Hazal Ceren Tugrul, Fatih Akın, Abdullah Akkus, Nihal Akcay, Ilyas Bingol, Oguz Dursun, Nazan Ulgen Tekerek, Alper Koker, Mutlu Uysal Yazıcı, Ebru Azapagasi, Nuri Alacakir, Caglar Odek, Didar Arslan, Faruk Ekinci, Ozden Ozgur Horoz, Ese Eda Turanli, Feyza Incekoy, Nilufer Yalindag Ozturk, Ali Ertug Arslankoylu, Mehmet Alakaya, Merve Misirlioglu, Resul Yilmaz, Ali Korulmaz, Ezgi Ozlem Ozmen, Ener Cagri Dinleyici   +44 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

International expert statement on training standards for critical care ultrasonography

, 2011
Training in ultrasound techniques for intensive care medicine physicians should aim at achieving competencies in three main areas: (1) general critical care ultrasound (GCCUS), (2) "basic" critical care echocardiography (CCE), and (3) advanced CCE.
Expert Round Table on Ultrasound in ICU, Haney, Michael,   +1 more
core   +1 more source

Interprofessional two-man team approach for interhospital transport of ARDS-patients under extracorporeal membrane oxygenation: a 10 years retrospective observational cohort study

BMC Anesthesiology, 2019
Background Extra Corporeal Membrane Oxygenation (ECMO) has become an accepted treatment option for severely ill patients. Due to a limited availability of ECMO support therapy, patients must often be transported to a specialised centre before or after ...
Stefan Felix Ehrentraut, Barbara Schroll, Stefan Lenkeit, Heidi Ehrentraut, Christian Bode, Stefan Kreyer, Florian Kögl, Felix Lehmann, Thomas Muders, Martin Scholz, Claudia Strater, Folkert Steinhagen, Nils Ulrich Theuerkauf, Carsten Weißbrich, Christian Putensen, Jens-Christian Schewe   +15 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source