Results 81 to 90 of about 7,575,842 (291)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Simple prognostic markers to predict mortality in intensive care unit: Red cell distribution width

, 2021
Background: We tried to examine association between the prognostic intensive care unit (ICU) scores and red cell distribution width (RDW) for prediction of mortality in a cohort of ICU patients at a single centre in Turkey.Methods: This is a ...
Erdogan, Ahmet, Uckan, Enes Malik, Erdem, Deniz, Tez, Mesut   +3 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Development and evaluation of the focused assessment of sonographic pathologies in the intensive care unit (FASP-ICU) protocol

, 2023
Background The use of ultrasonography in the intensive care unit (ICU) is steadily increasing but is usually restricted to examinations of single organs or organ systems.
Quintel, Michael, Schmidt, Stefan, Dieks, Jana-Katharina, Moerer, Onnen, Schmidt, Stefan; Department of Anesthesiology, Emergency and Intensive Care Medicine, University Hospital Goettingen, Georg August University, Goettingen, Germany, Quintel, Michael; Department of Anesthesiology, Emergency and Intensive Care Medicine, University Hospital Goettingen, Georg August University, Goettingen, Germany, Moerer, Onnen; Department of Anesthesiology, Emergency and Intensive Care Medicine, University Hospital Goettingen, Georg August University, Goettingen, Germany, Dieks, Jana-Katharina; Department of Pediatric Cardiology and Pediatric Intensive Care Medicine, University Hospital Goettingen, Georg August University, Goettingen, Germany   +7 more
core   +1 more source

Interprofessional two-man team approach for interhospital transport of ARDS-patients under extracorporeal membrane oxygenation: a 10 years retrospective observational cohort study

BMC Anesthesiology, 2019
Background Extra Corporeal Membrane Oxygenation (ECMO) has become an accepted treatment option for severely ill patients. Due to a limited availability of ECMO support therapy, patients must often be transported to a specialised centre before or after ...
Stefan Felix Ehrentraut, Barbara Schroll, Stefan Lenkeit, Heidi Ehrentraut, Christian Bode, Stefan Kreyer, Florian Kögl, Felix Lehmann, Thomas Muders, Martin Scholz, Claudia Strater, Folkert Steinhagen, Nils Ulrich Theuerkauf, Carsten Weißbrich, Christian Putensen, Jens-Christian Schewe   +15 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Determining the Difficulties of Parents with Children in Home Care Who Were Discharged from Intensive Care [PDF]

Introduction: This study was performed to determine the difficulties experienced by parents with children in home care who were discharged from intensive care.
Gülzade Uysal, Atiye Karakul, Duygu Sönmez Düzkaya, Gülçin Bozkurt, Tülay Yakut   +4 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Burden, risk factors, and outcomes respiratory syncytial virus (RSV) infection in pediatric intensive care units in Türkiye (RSVP Study 2020-2024)

BMC Pediatrics
Background Respiratory syncytial virus (RSV) is one of the leading causes of respiratory tract infections in infants and young children requiring a pediatric intensive care unit (PICU).
Yasemin Coban, Gultac Evren, Dincer Yildizdas, Neslihan Zengin, Alkan Bal, Tanıl Kendirli, Merve Havan, Eda Eyduran, Muhterem Duyu, Ayşe Aşık, Nazik Yener, Hatice Elif Kınık Kaya, Muhammed Udurgucu, Eylem Kiral, Gurkan Bozan, Mehmet Arda Kilinc, Nagehan Aslan, Mustafa Colak, Esra Sevketoglu, Seher Erdogan, Hazal Ceren Tugrul, Fatih Akın, Abdullah Akkus, Nihal Akcay, Ilyas Bingol, Oguz Dursun, Nazan Ulgen Tekerek, Alper Koker, Mutlu Uysal Yazıcı, Ebru Azapagasi, Nuri Alacakir, Caglar Odek, Didar Arslan, Faruk Ekinci, Ozden Ozgur Horoz, Ese Eda Turanli, Feyza Incekoy, Nilufer Yalindag Ozturk, Ali Ertug Arslankoylu, Mehmet Alakaya, Merve Misirlioglu, Resul Yilmaz, Ali Korulmaz, Ezgi Ozlem Ozmen, Ener Cagri Dinleyici   +44 more
doaj   +1 more source