Results 61 to 70 of about 984,139 (354)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

NURSING ATTENTION DEMANDS AT A NEONATAL, PEDIATRIC AND GENERAL INTENSIVE CARE UNIT

Cogitare Enfermagem, 2015
Descriptive and quantitative study to identify intensive nursing attention demands and the efforts these professionals make to cope with these demands.
Danilo Marcelo Araujo dos Santos, Francisca Georgina Macedo de Sousa, Thaís Marques Moreira, Andréa Cristina Oliveira Silva, Lorena Carvalho Braga   +4 more
doaj   +1 more source

Familycentred care in intensive care units

Southern African Journal of Critical Care, 2018
-
P J Jordan
doaj   +1 more source

The BRACELET Study: surveys of mortality in UK neonatal and paediatric intensive care trials. [PDF]

, 2010
BACKGROUND: The subject of death and bereavement in the context of randomised controlled trials in neonatal or paediatric intensive care is under-researched.
Allen, Elizabeth, Brocklehurst, Peter, Elbourne, Diana, Harvey, Sheila E, Platt, Martin P Ward, Snowdon, Claire, Tasker, Robert C   +6 more
core   +3 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Abdominal physical examinations in early stages benefit critically ill patients without primary gastrointestinal diseases: a retrospective cohort study

Frontiers in Medicine
BackgroundGastrointestinal (GI) function is critical for patients in intensive care units (ICUs). Whether and how much critically ill patients without GI primary diseases benefit from abdominal physical examinations remains unknown.
Xiao Cui, Yu Shi, Xinlei He, Mingyuan Zhang, Hua Zhang, Jianhong Yang, Yuxin Leng   +6 more
doaj   +1 more source

Pitfalls in the Diagnosis and Management of Invasive Pneumococcal Meningoencephalitis – What We Can Learn From a Case

Clinical Medicine Insights: Case Reports, 2017
Invasive pneumococcal meningitis is a life-threatening infectious disease affecting the central nervous system. It continues to be the most common type of community-acquired acute bacterial meningitides.
Pascale S Grzonka, Raoul Sutter
doaj   +1 more source

Does early tracheostomy affect the duration of mechanical ventilation in patients with severe traumatic head injuries?

The Egyptian Journal of Otolaryngology, 2018
Background and purpose Tracheostomy is a surgical procedure performed frequently in intensive care units (ICUs). Prolonged mechanical ventilation (MV) is the main indication for tracheostomy in ICUs.
M. M. Roushdy, H. S. Abdel-Ghaffar, Ahmed Ezzat Mohamed Saleh   +2 more
doaj   +1 more source

Nosocomial infections in the intensive care units [PDF]

, 2006
Background/Aim. The risk for nosocomial infections (NIs) is 5-10 times higher in patients hospitalized in the Intensive Care Units (ICUs) than in patients staying in other wards.
Jovanović Biljana, Jovanović Snežana, Mazić Nataša, Mioljević Vesna, Obrenović Jelena   +4 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source