Results 61 to 70 of about 969,027 (312)

Nosocomial infections in the intensive care units [PDF]

, 2006
Background/Aim. The risk for nosocomial infections (NIs) is 5-10 times higher in patients hospitalized in the Intensive Care Units (ICUs) than in patients staying in other wards.
Jovanović Biljana, Jovanović Snežana, Mazić Nataša, Mioljević Vesna, Obrenović Jelena   +4 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Focus on Italian hyperbaric centers: lights and shadows in the pediatric field. [PDF]

Pediatric Anesthesia and Critical Care Journal (PACCJ)
Hyperbaric oxygen therapy (HBOT) is often underesti- mated due to limited awareness of its therapeutic poten- tial and the scarce availability of specialized centers in Italy, whose distribution across the country is highly un- even.
M. Ciuffreda, S. Sorrenti, L. Brugiaferri, E. Pisello, G. Ledda, C. Piangatelli, D. Galante   +6 more
doaj   +1 more source

The role of microbiological monitoring in the system of epidemiological surveillance of hospital infections [PDF]

, 2017
Analysis of the prevalence of etiologic structure and antibiotic resistance profile of pathogens associated with health care (HAI) in surgical and intensive care units of the Belgorod Regional Clinical Hospital of St.
Bashkirev, A. A., Chephranova, Zh. Yu, Kalyuzhnaya, E. V., Zemlyanskaya, L. O., Zemlyansky, O. A.   +4 more
core   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Bőrápolási gyakorlat a Neonatális Intenzív Centrumokban Magyarországon [PDF]

, 2014
Bevezetés: A kora- és újszülöttek bőrének fiziológiája és tudományos alapokon nyugvó ápolási gyakorlata kevéssé ismert terület a betegellátók számára.
Csoma, Zsanett, Doró, Péter, Machay, Tamás, Szabó, Miklós, Tálosi, Gyula   +4 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Nutrition in Pediatric Intensive Care Units

Journal of Pediatric Emergency and Intensive Care Medicine, 2023
The limited energy stores and fast metabolism of sick children in the intensive care unit, as well as the intense stress caused by the critical illness, reveal the importance of nutrition.
Hasan Ağın, Ali Ertuğ Arslanköylü, Nazik Aşılıoğlu Yener, Ayşe Berna Anıl, Oğuz Dursun, Tanıl Kendirli, Dinçer Yıldızdaş   +6 more
doaj   +1 more source