Results 91 to 100 of about 233,101 (310)

2470. A Survey of the Collection of Denominator Data in the Korean National Healthcare-associated Infections Surveillance System (KONIS), Intensive Care Unit Module [PDF]

, 2023
Yee Gyung Kwak, Mi Suk Lee
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Batrachochytrium salamandrivorans (Bsal) not detected in an intensive survey of wild North American amphibians. [PDF]

Sci Rep, 2020
Waddle JH, Grear DA, Mosher BA, Grant EHC, Adams MJ, Backlin AR, Barichivich WJ, Brand AB, Bucciarelli GM, Calhoun DL, Chestnut T, Davenport JM, Dietrich AE, Fisher RN, Glorioso BM, Halstead BJ, Hayes MP, Honeycutt RK, Hossack BR, Kleeman PM, Lemos-Espinal JA, Lorch JM, McCreary B, Muths E, Pearl CA, Richgels KLD, Robinson CW, Roth MF, Rowe JC, Sadinski W, Sigafus BH, Stasiak I, Sweet S, Walls SC, Watkins-Colwell GJ, White CL, Williams LA, Winzeler ME.   +37 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Patients with faecal peritonitis admitted to European intensive care units: an epidemiological survey of the GenOSept cohort [PDF]

, 2013
Ascanio Tridente, Geraldine M Clarke, Andrew Walden, Stuart McKechnie, Paula Hutton, Gary Mills, Anthony Gordon, Paul Holloway, Jean‐Daniel Chiche, Julian Bion, Frank Stüber, Christopher S. Garrard, Charles Hinds, C. J. Hinds   +13 more
openalex   +1 more source

[Treatment of sepsis-induced coagulopathy : Results of a Germany-wide survey in intensive care units].

, 2021
Thomas Schmoch, Thorsten Brenner, Andrea Becker-Pennrich, Ludwig Christian Hinske, Markus A. Weigand, Josef Briegel, Patrick Möhnle,   +7 more
openalex   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A national survey on routines regarding sedation in Swedish intensive care units

Upsala Journal of Medical Sciences, 2019
Background: Previous studies concerning sedation in Swedish intensive care units (ICU) have shown variability in drug choices and strategies. Currently, there are no national guidelines on this topic.
Oskar Talsi, Ritva Kiiski Berggren, Göran Johansson, Ola Winsö   +3 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source