Results 81 to 90 of about 1,415,466 (305)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Survey of information technology in Intensive Care Units in Ontario, Canada

open access: yesBMC Medical Informatics and Decision Making, 2008
Background The Intensive Care Unit (ICU) is a data-rich environment where information technology (IT) may enhance patient care. We surveyed ICUs in the province of Ontario, Canada, to determine the availability, implementation and variability of ...
Hallett David   +4 more
doaj   +1 more source

Threatened Fishes of Arkansas [PDF]

open access: yes, 1974
Intensive field collecting throughout Arkansas and a survey of literature and museum records revealed 37 fish species and subspecies in Arkansas to be threatened by human activities. Of these 37 threatened forms, seven are considered rare and endangered.
Robison, Henry W.
core   +2 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

open access: yes
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana   +8 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Camera-traps are a cost-effective method for surveying terrestrial squamates: A comparison with artificial refuges and pitfall traps.

open access: yesPLoS ONE, 2020
INTRODUCTION:Fundamental data on the distributions, diversity, and threat status of terrestrial snakes and lizards (hereafter squamates) is limited.
Dustin J Welbourne   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

USE OF GOBBLING COUNTS TO MONITOR THE DISTRIBUTION AND ABUNDANCE OF WILD TURKEYS

open access: yesWildlife Society Bulletin, 1980
Two forms of call count surveys were used to monitor populations of wild turkeys (Meleagris gallopavo) in Minnesota during 1973‐1979. An intensive survey involving daily counts of gobblers during 1 April‐15 June was conducted annually on 2 routes.
William F. Porter, John R. Ludwig
doaj   +1 more source

A Survey of Rounding Practices in Canadian Adult Intensive Care Units.

open access: yesPLoS ONE, 2015
ObjectiveTo describe rounding practices in Canadian adult Intensive Care Units (ICU) and identify opportunities for improvement.DesignMixed methods design.
Jessalyn K Holodinsky   +6 more
doaj   +1 more source

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