Results 21 to 30 of about 346,816 (197)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Comportamiento de las tasas de interés reales en Ecuador en el período 1995-2003
, 2004 El presente trabajo de investigación busca dar al lector un panorama general del comportamiento de las tasas de interés reales en el Ecuador durante el período de análisis comprendido entre 1995 y 2003. El estudio consta de cinco capítulos. En el primero
Pico Pita, Augusto Enrique
core +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Revista de Interés Público (REDIP) | Año 1 | Número 1
, 2017 La Revista de Interés Público (REDIP) de la Secretaría de Extensión Universitaria de la Facultad de Ciencias Jurídicas y Sociales, nace como consecuencia de la observación del desarrollo creciente entre nuestras prácticas constitucionales, de una forma ...
Revista de Interés Público
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Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Revista de Interés Público | Año 1 | Número 2
, 2018 Presentación Artículos - Derechos de desestabilización: el triunfo del Litigio de Interés Público | Charles F. Sabel, William H. Simon-Traducción al español de María Emilia Mamberti - El nuevo derecho de interés público: una mirada hacia atrás a la ...
Revista de Interés Público
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Criterios de valoración de bienes de interés constructivo para el desarrollo de la base de datos SIBICo, aplicados al estudio de caso Bd Bacatá [PDF]
, 2017 ilustraciones, diagramas, fotografíasEl presente trabajo de investigación desarrollo los criterios de valoración de una edificación desde su componente descriptivo hasta el análisis de sus características con el fin de determinar si se considera este un “
Santos Castellanos, Luz Adriana
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