Results 221 to 230 of about 3,623,641 (323)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Challenges in predicting protein-protein interactions of understudied viruses: Arenavirus-human interactions. [PDF]

Comput Struct Biotechnol J
Sahni H, Crotzer SM, Moore J, Branda SS, Estrada T, Gnanakaran S.   +5 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Learning collective multicellular dynamics with an interacting mean field neural SDE model. [PDF]

PLoS Comput Biol
Jiang Q, Li L, Zhang L, Wan L.
europepmc   +1 more source

Deciphering the PgLEA2-50 interactome: implications for abiotic stress responses in <i><b>Panax ginseng</b></i>. [PDF]

Plant Signal Behav
Wang Q, Liu J, Zhang M, Wang P, Li T, Bian X, Chen X, Chen S, Wang L, Lei J, Han L, Xu M, Zhang Q, Lei X, Wang Y, Sun X.   +15 more
europepmc   +1 more source

Multiple origins and functions: evolutionary pathways of HSP70 proteins in viruses. [PDF]

J Gen Virol
Maachi A, Elena SF.
europepmc   +1 more source

Advances in protein-protein interaction prediction: a deep learning perspective. [PDF]

Front Bioinform
Alkhateeb N, Awad M.
europepmc   +1 more source