Results 151 to 160 of about 68,989 (290)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
From Traditional Tasks to Hyperscanning: Exploratory Evidence for Selective Modulation of Sensorimotor Neurodynamics Using Time-Resolved Generalized Additive Model Analysis. [PDF]
Parada FJ, Grasso-Cladera A, Rossi A.
europepmc +1 more source
The first textbook dedicated to interactional linguistics, focusing on linguistic analyses of conversational phenomena, this introduction provides an overview of the theory and methodology of interactional linguistics.
Selting, Margret +1 more
core
The ubiquitin system in normal and infected germinal center B cells
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Rethinking AI in clinical decision support: a framework for reciprocal human-AI interaction. [PDF]
Greengrass CJ.
europepmc +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Kern F. Interactional Linguistics. In: Cummings L, ed. Pragmatics Encyclopedia.
Cummings, Louise +1 more
core
Smaller is better: nanobodies meet NMR
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
When Medicine Gets Irritating: Interactional and Structural Triggers of Uncertainty in Family Medicine Residency Training. [PDF]
Hierasimowicz K +2 more
europepmc +1 more source

