Results 1 to 10 of about 16,557,675 (399)

The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis

open access: yesNature Communications, 2021
Diabetes is characterized by dysfunction and loss of beta-cells, and promoting beta-cell survival is of therapeutic interest. Here the authors show that Large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, induces beta-cell ...
Ting Yuan   +13 more
doaj   +1 more source

Strain-level characterization of broad host range mobile genetic elements transferring antibiotic resistance from the human microbiome

open access: yesNature Communications, 2022
Here, Forster et al. compare 1354 cultured commensal strains (540 species) to 45,403 pathogen strains (12 species), identifying 64,188 MGE-mediated antibiotic resistance gene transfer events between the two groups, and show that 15 broad host range MGEs ...
Samuel C. Forster   +12 more
doaj   +1 more source

A symbiotic footprint in the plant root microbiome

open access: yesEnvironmental Microbiome, 2023
Background A major aim in plant microbiome research is determining the drivers of plant-associated microbial communities. While soil characteristics and host plant identity present key drivers of root microbiome composition, it is still unresolved ...
Kyle Hartman   +6 more
doaj   +1 more source

ECS1 and ECS2 suppress polyspermy and the formation of haploid plants by promoting double fertilization

open access: yeseLife, 2023
The current pace of crop plant optimization is insufficient to meet future demands and there is an urgent need for novel breeding strategies. It was previously shown that plants tolerate the generation of triparental polyspermy-derived plants and that ...
Yanbo Mao   +6 more
doaj   +1 more source

Host adaptation in gut Firmicutes is associated with sporulation loss and altered transmission cycle

open access: yesGenome Biology, 2021
Background Human-to-human transmission of symbiotic, anaerobic bacteria is a fundamental evolutionary adaptation essential for membership of the human gut microbiota.
Hilary P. Browne   +10 more
doaj   +1 more source

Elucidation of Essential Genes and Mutant Fitness during Adaptation toward Nitrogen Fixation Conditions in the Endophyte Azoarcus olearius BH72 Revealed by Tn-Seq

open access: yesMicrobiology Spectrum, 2022
Azoarcus olearius BH72 is a diazotrophic model endophyte that contributes fixed nitrogen to its host plant, Kallar grass, and expresses nitrogenase genes endophytically.
Theresa Harten   +3 more
doaj   +1 more source

Interactive Interaction Constraints [PDF]

open access: yes, 2013
Interaction constraints are an expressive formalism for describing coordination patterns, such as those underlying the coordination language Reo, that can be efficiently implemented using constraint satisfaction technologies such as SAT and SMT solvers. Existing implementations of interaction constraints interact with external components only in a very
Paiva Proenca, Jose, Clarke, Dave
openaire   +1 more source

INTERACTING INTERSECTIONS [PDF]

open access: yesInternational Journal of Modern Physics A, 1998
Intersecting p-branes can be viewed as higher-dimensional interpretations of multicharge extremal p-branes, where some of the individual p-branes undergo diagonal dimensional oxidation, while the others oxidize vertically. Although the naive vertical oxidation of a single p-brane gives a continuum of p-branes, a more natural description arises if one ...
Lü, H., Pope, C. N.
openaire   +3 more sources

Reconceptualizing sex, brain and psychopathology: interaction, interaction, interaction [PDF]

open access: yesBritish Journal of Pharmacology, 2014
In recent years there has been a growing recognition of the influence of sex on brain structure and function, and in relation, on the susceptibility, prevalence and response to treatment of psychiatric disorders. Most theories and descriptions of the effects of sex on the brain are dominated by an analogy to the current interpretation of the effects of
D, Joel, R, Yankelevitch-Yahav
openaire   +2 more sources

Isopod holobionts as promising models for lignocellulose degradation

open access: yesBiotechnology for Biofuels, 2020
Background Isopods have colonized all environments, partly thanks to their ability to decompose the organic matter. Their enzymatic repertoire, as well as the one of their associated microbiota, has contributed to their colonization success.
Marius Bredon   +5 more
doaj   +1 more source

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