Results 1 to 10 of about 4,078,125 (220)

The (In)Efficiency of interaction [PDF]

open access: yesProceedings of the ACM on Programming Languages, 2021
Evaluating higher-order functional programs through abstract machines inspired by the geometry of the interaction is known to induce space efficiencies, the price being time performances often poorer than those obtainable with traditional, environment-based, abstract machines.
Accattoli B., Dal Lago U., Vanoni G.
openaire   +6 more sources

The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis

open access: yesNature Communications, 2021
Diabetes is characterized by dysfunction and loss of beta-cells, and promoting beta-cell survival is of therapeutic interest. Here the authors show that Large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, induces beta-cell ...
Ting Yuan   +13 more
doaj   +1 more source

Strain-level characterization of broad host range mobile genetic elements transferring antibiotic resistance from the human microbiome

open access: yesNature Communications, 2022
Here, Forster et al. compare 1354 cultured commensal strains (540 species) to 45,403 pathogen strains (12 species), identifying 64,188 MGE-mediated antibiotic resistance gene transfer events between the two groups, and show that 15 broad host range MGEs ...
Samuel C. Forster   +12 more
doaj   +1 more source

A symbiotic footprint in the plant root microbiome

open access: yesEnvironmental Microbiome, 2023
Background A major aim in plant microbiome research is determining the drivers of plant-associated microbial communities. While soil characteristics and host plant identity present key drivers of root microbiome composition, it is still unresolved ...
Kyle Hartman   +6 more
doaj   +1 more source

ECS1 and ECS2 suppress polyspermy and the formation of haploid plants by promoting double fertilization

open access: yeseLife, 2023
The current pace of crop plant optimization is insufficient to meet future demands and there is an urgent need for novel breeding strategies. It was previously shown that plants tolerate the generation of triparental polyspermy-derived plants and that ...
Yanbo Mao   +6 more
doaj   +1 more source

Host adaptation in gut Firmicutes is associated with sporulation loss and altered transmission cycle

open access: yesGenome Biology, 2021
Background Human-to-human transmission of symbiotic, anaerobic bacteria is a fundamental evolutionary adaptation essential for membership of the human gut microbiota.
Hilary P. Browne   +10 more
doaj   +1 more source

Elucidation of Essential Genes and Mutant Fitness during Adaptation toward Nitrogen Fixation Conditions in the Endophyte Azoarcus olearius BH72 Revealed by Tn-Seq

open access: yesMicrobiology Spectrum, 2022
Azoarcus olearius BH72 is a diazotrophic model endophyte that contributes fixed nitrogen to its host plant, Kallar grass, and expresses nitrogenase genes endophytically.
Theresa Harten   +3 more
doaj   +1 more source

Interactive Unawareness [PDF]

open access: yesSSRN Electronic Journal, 2003
The standard state-spaces of asymmetric information preclude non-trivial forms of unawareness (Modica and Rustichini, 1994, Dekel, Lipman and Rustichini, 1998). We introduce a generalized state-space model that allows for non-trivial unawareness among several individuals, and which satisfies strong properties of knowledge as well as all the desiderata ...
HEIFETZ, Aviad   +2 more
openaire   +7 more sources

Interactive Interaction Constraints [PDF]

open access: yes, 2013
Interaction constraints are an expressive formalism for describing coordination patterns, such as those underlying the coordination language Reo, that can be efficiently implemented using constraint satisfaction technologies such as SAT and SMT solvers. Existing implementations of interaction constraints interact with external components only in a very
José Proença, Dave Clarke
openaire   +2 more sources

Critical structural elements for the antigenicity of wheat allergen LTP1 (Tri a 14) revealed by site-directed mutagenesis

open access: yesScientific Reports, 2022
Lipid transfer proteins (LTPs) were identified as allergens in a large variety of pollens and foods, including cereals. LTPs belong to the prolamin superfamily and display an α-helical fold, with a bundle of four α-helices held together by four disulfide
Hamza Mameri   +12 more
doaj   +1 more source

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