Results 151 to 160 of about 16,557,675 (399)

Electronic Zero-Point Oscillations in the Strong-Interaction Limit of Density Functional Theory

, 2009
Paola Gori‐Giorgi, Giovanni Vignale, Michael Seidl   +2 more
openalex   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Quantitative Proteomics Reveals Protein–Protein Interactions with Fibroblast Growth Factor 12 as a Component of the Voltage-Gated Sodium Channel 1.2 (Nav1.2) Macromolecular Complex in Mammalian Brain*

, 2015
Norelle C. Wildburger, Syed R. Ali, Jim Hsu, Alexander S. Shavkunov, Miroslav N. Nenov, Cheryl F. Lichti, Richard D. LeDuc, Ekaterina Mostovenko, Neli I. Panova-Elektronova, Mark R. Emmett, Carol L. Nilsson, Fernanda Laezza   +11 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Networks beyond pairwise interactions: structure and dynamics [PDF]

Physics reports, 2020
F. Battiston, G. Cencetti, Iacopo Iacopini, V. Latora, M. Lucas, Alice Patania, Jean-Gabriel Young, G. Petri   +7 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1

, 2018
Jenny U. Johansson, William D. Brubaker, Harold S. Javitz, Andrew W. Bergen, Denise Nishita, Abhishek Trigunaite, Andrés B Crane, Justine Ceballos, Diego Mastroeni, Andrea J. Tenner, Marwan N. Sabbagh, Joseph Rogers   +11 more
openalex   +2 more sources

Selective tetraspan–integrin complexes (CD81/α4β1, CD151/α3β1, CD151/α6β1) under conditions disrupting tetraspan interactions [PDF]

, 1999
Valérie Serru, LE NAOUR François, Martine Billard, David O. Azorsa, François Lanza, Claude Boucheix, Eric Rubinstein   +6 more
openalex   +1 more source

Verification of protein structures: Patterns of nonbonded atomic interactions

Protein Science, 1993
Chris Colovos, T. Yeates
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source