Results 111 to 120 of about 2,600,111 (291)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Metadiscourse in Lithuanian linguistics research articles: A study of interactive and interactional features

Kalbotyra
In the recent decades the interpersonal nature of written academic communication has been widely studied in various linguistic/cultural contexts, including Lithuanian.
Anna Ruskan, Greta Maslauskienė
doaj   +1 more source

Interactive information retrieval [PDF]

, 2008
Allan, Barry, Bates, Beaulieu, Beaulieu, Belkin, Belkin, Bhavnani, Blair, Borgman, Borgman, Brajnik, Broder, Buyukkokten, Byström, Campbell, Case, Chen, Cove, Crestani, Crouch, Downie, Dumais, Eastman, Efthimiadis, Ellis, Ellis, Fidel, Ford, Ford, Foster, Fox, Hansen, Harper, Hearst, Hearst, Hearst, Heinström, Hill, Ingwersen, Ingwersen, Jansen, Jansen, Jones, Jones, Kang, Kelly, Kelly, Kim, Konstan, Kruschwitz, Kuhlthau, Legg, Lin, Lin, Lorigo, Lynch, López-Ostenero, Maña-López, Niemi, Norman, Over, Pirkola, Pu, Radev, Reid, Reid, Riedl, Rieh, Robertson, Rosenfeld, Roussinov, Ruthven, Ruthven, Savolainen, Shipman, Shneiderman, Sihvonen, Slone, Smeaton, Spink, Spink, Spink, Spink, Spink, Spink, Spärck Jones, Spärck Jones, Sweeney, Tombros, Tombros, Toms, Topi, Topi, Vakkari, Vakkari, Vakkari, Vakkari, van der Eijk, Vechtomova, Voorhees, White, White, White, White, Wiesman, Wu, Xie   +107 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Interactive Unawareness [PDF]

The standard state-spaces of asymmetric information preclude non-trivial forms of unawareness (Modica and Rustichini, 1994, Dekel, Lipman and Rustichini, 1998).
Heifetz, Aviad, Meier, Martin, Schipper, Burkhard C.   +2 more
core