Results 101 to 110 of about 15,117 (267)

Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

Angewandte Chemie International Edition, EarlyView.
To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham, Tess M. Weber, Nader N. Nasief, Lorenz Mayer, Frederik W. Hacker, Ekaterina Hermann, Mareike B. Möllers, Yuliia Skliarenko, Tahereh Damghani, Abid N. Manzar, Kaly S. Lin, Ramona Rudalska, Marcia I. Goettert, Lars Zender, Daniel Dauch, Michael Forster, Stefan A. Laufer, David E. Heppner   +20 more
wiley   +1 more source

Bistable Switching of π‐Conjugation in a Dithienylethene‐Bridged Luminescent Trityl Diradicaloid

Angewandte Chemie International Edition, EarlyView.
Photoswitches that affect π‐conjugation offer a powerful strategy for external manipulation of luminescent diradicals. Dithienylethene‐linked persistent trityl diradicaloids, DTE‐TTM2 and F6‐DTE‐TTM2, exhibit bistable switching of their optical, electrochemical and magnetic properties.
Xingmao Chang, Sören Schlittenhardt, Julia Zolg, Maximilian Herm, Siyang He, Vivek Chandrakant Wakchaure, Dinar Abdullin, Robert Göstl, Dirk M. Guldi, Alexander J. C. Kuehne, Sabine Richert, Max von Delius   +11 more
wiley   +1 more source

Discovery of the Cyclic Form of MRI pH‐Sensor Z‐OMPD Enables >5% 13C Hyperpolarization by SABRE

Angewandte Chemie International Edition, EarlyView.
With “c‐OMPD”, we discovered a previously unknown 5‐membered lactol structure that arises from the homoaldol condensation of the central metabolite pyruvic acid. We demonstrate that the cyclization equilibrium is of crucial importance for OMPD's function as MRI‐based pH sensor and achieve for the first time 13C polarization levels (>5%) by SABRE in the
Juanita Ferreira, Ivan A. Trofimov, Martin Grashei, Adriana Sacristán‐Martín, Alexander Huber, David Schleicher, Oleksiy Khavryuchenko, Franz Schilling, Andreas B. Schmidt, Max von Delius   +9 more
wiley   +1 more source

Preparation of MOEAMCl and MAAm Based Hydrogels and Effective Use in Anionic Dye Adsorption

Journal of Applied Polymer Science, Volume 142, Issue 16, April 20, 2025.
ABSTRACT In this study, hydrogels based on [2‐(Methacryloyloxy)ethyl]trimethylammonium chloride (MOEAMCl) and methacrylamide (MAAm) were synthesized for the removal of anionic dyes from aqueous solutions. Following detailed characterization, the use of hydrogels for methyl orange (MO) adsorption was investigated.
Hilal Nur Duykop Demir, Ali Delibaş, Ayşe Benk, Ramazan Coşkun   +3 more
wiley   +1 more source

Origin, evolution and biogeographic dynamics of the European rabbit (Oryctolagus cuniculus) in Southwestern Europe

The Anatomical Record, EarlyView.
Abstract The Pleistocene is a key period for understanding the evolutionary history and palaeobiogeography of the European rabbit (Oryctolagus cuniculus). The species was first documented in southeastern Iberia at the beginning of the Middle Pleistocene and appears to have rapidly spread throughout Southwestern Europe, where it was found in numerous ...
Maxime Pelletier
wiley   +1 more source

Tracheal chambers as a key innovation for high‐frequency emission in bat echolocation

The Anatomical Record, EarlyView.
Abstract Key innovations are pivotal for biodiversity and facilitating evolutionary success, enabling organisms' adaptation to various ecological niches through the diversification of phenotypic traits. In mammals, notable adaptations include evolving hypsodonty for grazing on grasses and, for bats, evolving echolocation and wing acquisition.
Nicolas L. M. Brualla, Laura A. B. Wilson, Khizar Hayat, Michael Doube, Vuong Tan Tu, Thongchai Ngamprasertwong, Thanakul Wannaprasert, Daisuke Koyabu   +7 more
wiley   +1 more source

Extreme signal amplitude events in neuromagnetic oscillations reveal brain aging processing across adulthood

Frontiers in Aging Neuroscience
IntroductionNeurophysiological activity, as noninvasively captured by electro- and magnetoencephalography (EEG and MEG), demonstrates complex temporal fluctuations approximated by typical variations around the mean values and rare events with large ...
Vasily A. Vakorin, Vasily A. Vakorin, Hayyan Liaqat, Sam M. Doesburg, Sylvain Moreno   +4 more
doaj   +1 more source

Deciphering the Palimpsest: Chronological Uncertainty and the Interpretation of Mining Landscapes at Písečný vrch (Czech Republic)

Archaeological Prospection, EarlyView.
ABSTRACT We investigated the Písečný vrch (Czech Republic), a site exploited for quartz mining in both prehistoric times and the 20th century. Due to their morphological similarity across all mining periods, the differentiation between pits with archaeological potential and recent ones is challenging.
Jan Fišer, Petr Krištuf, Jan Kropáček, Vojtěch Barták, Lenka Starková, Vítězslav Moudrý   +5 more
wiley   +1 more source

The Art of Interaction: Interactivity, Performativity, and Computers

The Journal of Aesthetics and Art Criticism, 1997
Dans le cadre d'un dossier consacre aux perspectives de l'art et de la technologie, l'A. souleve la question de la performance de l'art computationnel interactif et montre que celui-ci s'apparente aux arts performatifs traditionnels en ce concerne le statut ontologique et semiotique de l'oeuvre d'art.
openaire   +1 more source

The beauty of experiential learning in anatomy

Anatomical Sciences Education, EarlyView.
Abstract Anatomy is a unique subject where one must learn by doing. This is achieved through a variety of methods like dissection, use of prosections, imaging, playful learning (crocheting structures, drawing, and painting organs), through functional movement like yoga or pilates, use of 3D plastic models or by immersing oneself in virtual or augmented
Bipasha Choudhury, Ingrid Gouldsborough
wiley   +1 more source