Results 211 to 220 of about 270,110 (298)

mViSE: A visual search engine for analyzing multiplex IHC brain tissue images (spatial proteomics). [PDF]

Sci Rep
Huang L, Mills R, Mandula S, Bai L, Jeyhani M, Redell J, Nguyen H, Prasad S, Maric D, Roysam B.   +9 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

scSelector: A Flexible Single-Cell Data Analysis Assistant for Biomedical Researchers. [PDF]

Genes (Basel)
Gao X, Wu P, Yu J, Zhu X, Zhang S, Shao H, Lu D, Hou X, Liu Y.   +8 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Genetic variations interact with polybrominated diphenyl ether exposure to alter lipid homeostasis. [PDF]

Nat Commun
Hu N, Li B, Lu Y, Jiang Q, Zhu Y, Li Z, Qu Y, Qiu T, Zhang D, Wang Z, Ma Y, Jin H, Sun P, Song H, Zhao Y, Zhao Y, Zhang M, Zhao F, Ji S, Yuan B, Zhu Y, Lv Y, Tian J, Miao X, Shi X.   +24 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

PRISM: a Python package for interactive and integrated analysis of multiplexed tissue microarrays. [PDF]

NAR Genom Bioinform
Tubelleza R, Kilgallon A, Tan CW, Monkman J, Fraser JF, Kulasinghe A.   +5 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

An interactive cascaded deep learning framework with expert refinement for accurate striatal subregion segmentation. [PDF]

Sci Rep
Kim J, Kim D, Kim S, Suh M, Yoo SW, Lee JS, Yoon HJ.   +6 more
europepmc   +1 more source