Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Characteristics of sports brand content on social media and their effects on consumers. [PDF]
Front Sports Act LivingLiu Y.
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Technology Empowers Emotions: How AR Technology Triggers Consumers' Purchase and Spread Behavior Towards Intangible Cultural Heritage Brands. [PDF]
Behav Sci (Basel)Sheng Y, Zhao J, Jung E.
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Impact of content features of digital micro-dramas on active aging: the serial mediation effect of emotional engagement and social connectedness. [PDF]
Front PsycholLi W, Cheng S, Ling S, Zheng C.
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Re-conceptualising picturebook theory in the digital age
Barnelitterært Forskningstidsskrift, 2015 Ghada Al-Yaqout, Maria Nikolajva
doaj +1 more source
Perceived AI interactivity and Chinese EFL learners' motivated learning behaviors: the moderating role of daily AI usage duration. [PDF]
Front PsycholMin G, Jiazhu L.
europepmc +1 more source