Results 81 to 90 of about 10,129 (256)

Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy

Advanced Science, EarlyView.
A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru, Priyanka Bhattacharyya, Mingxu You   +2 more
wiley   +1 more source

2H-1,4-Benzoxazin-3(4H)-one linked 1,2,3-triazole derivatives and their study on inducing DNA damage in tumor cells

Frontiers in Pharmacology
This study explores the anticancer potential of rigid planar compounds capable of intercalating into tumor cell DNA, thereby inducing DNA damage and subsequent cell death. A novel series of compounds (c1–c20) were synthesized using 2H-1,4-benzoxazin-3(4H)
Xixi Hou, Yajie Guo, Xi Wang, En Gao, En Gao, Jianxue Yang   +5 more
doaj   +1 more source

Phase Fraction Modulation Enhances Li+/Na+ Diffusion Disparity in Spent LiFePO4 Cathodes for Efficient Lithium Extraction from Brine

Advanced Science, EarlyView.
A direct cascaded utilization strategy for spent LiFePO4 batteries efficiently extracts lithium from brine, embodying the “urban mining” concept. Phase fraction modulation revealed its significant impact on local bond lengths of crystal structure and the Li/Na diffusion energy barrier, identifying the best material (Li0.19FePO4) for lithium extraction.
Ruiqi Yin, Qihan Huang, Jiayu Hao, Guosheng Li, Guoxing Ren, Dongfu Liu, Zhongwei Zhao, Wenhua Xu   +7 more
wiley   +1 more source

Synthesis, ADME, and In Silico Molecular Docking Study of Novel N-Substituted β-Carboline Analogs as a Potential Anticancer Agent

Chemistry Proceedings
The present study designed and computationally optimized a series of novel β-carboline derivatives to investigate the interaction between designed ligands and selected proteins.
Sunil Gaikwad
doaj   +1 more source

Electrostatic Self‐Assembly Induced Nest‐Like MXene Networks on Fabric for Ultra‐Broadband Flexible Absorption

Advanced Science, EarlyView.
In this study, an electrostatically self‐assembled WPU‐MXene@FC flexible fabric constructs a “nest‐like” structure on fibers, building construct MXene multiple loss paths, achieving ultra‐wideband absorption of 25.3–1200 GHz in a thickness of 1.8 mm, while also exhibiting superhydrophobicity, acid and alkali resistance, and bending resistance ...
Min Luo, Zihao Chen, Haotian Li, Kexun Li, Wei Wang, Weishi Jiao, Donghong Wang, Qiye Wen   +7 more
wiley   +1 more source

N‐Doping Activated Presodiation Enhances Sodium‐Ion Provision in Hard Carbon Anodes

Advanced Science, EarlyView.
Introducing pyrrolic‐N sites enables efficient presodiation and stronger PF6− capture, thus pre ‐ forming a robust inorganic‐rich SEI layer in hard carbon anodes. ABSTRACT Hard carbon (HC) is considered the most promising anode material for commercial sodium‐ion batteries (SIBs), yet it still faces critical challenges such as low initial Coulombic ...
Hua Lin, Wenxing Miao, Yanrong Shi, Guangyi Mao, Ding Ding, Jian Weng, Zhongxiong Fan, Qingchi Xu, Jun Xu   +8 more
wiley   +1 more source

Ultra‐Low Intensity Continuous Wave Laser Ablation Propulsion With Graphene‐Engineered Wood

Advanced Science, EarlyView.
Graphene delignified wood converts continuous wave laser energy into thrust. Laser propulsion experiments in vacuum reveal the lowest laser ablation threshold intensities and the greatest density‐normalized specific impulse in literature. The results highlight graphene delignified wood as a potential efficient, sustainable, strong, and lightweight ...
Afnan S. M. Elmubasher, Rami Elkaffas, Mohamed Hamid Salim, Basel Altawil, Chanaka Sandaruwan, Shanavas Shajahan, Ahsan Baidar Bakht, Irfan Hussain, Blaise L. Tardy, Sean S. M. Swei, Yarjan Abdul Samad   +10 more
wiley   +1 more source

Vibrio cholerae OmpR Represses the ToxR Regulon in Response to Membrane Intercalating Agents That Are Prevalent in the Human Gastrointestinal Tract. [PDF]

Infect Immun, 2020
Kunkle DE, Bina TF, Bina XR, Bina JE.
europepmc   +1 more source

A Cationic Supramolecule With Potent Antifungal Activity, Single‐Species Selectivity, and Strong Synergy With Echinocandins

Advanced Science, EarlyView.
We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai, Adrielle Xianwen Chen, Eve Wai Ling Chow, Li Mei Pang, Jianguo Li, Chandra Shekhar Verma, Stefan H. Oehlers, Yue Wang, Ning Li   +8 more
wiley   +1 more source

V2CTx MXene as a Sacrificial Promoter for NiFe Catalyst for Anion Exchange Membrane Electrolyzers

Advanced Science, EarlyView.
These findings demonstrate that V2CTx functions beyond passive conductive support as an active electronic participant whose structural legacy sustains durable performance even after vanadium leaching in Anion Exchange Membrane (AEM) Electrolysers. ABSTRACT Nickel‐iron layered double hydroxides (NiFe‐LDH) show excellent activity, their poor conductivity
Bastian Schmiedecke, Can Kaplan, Karuppasamy Dharmaraj, Axel Zuber, Merve Buldu‐Aktürk, Ningjun Chen, Mailis Lounasvuori, Xuyun Guo, Valeria Nicolosi, Thorsten Schultz, Norbert Koch, Johanna Rosen, Michelle P. Browne   +12 more
wiley   +1 more source