Results 51 to 60 of about 164,295 (306)

Endotheliopathy and Platelet Dysfunction as Hallmarks of Fatal Lassa Fever

Emerging Infectious Diseases, 2020
Lassa fever (LF) causes multisystem disease and has a fatality rate
Lucy E. Horton, Robert W. Cross, Jessica N. Hartnett, Emily J. Engel, Saori Sakabe, Augustine Goba, Mambu Momoh, John Demby Sandi, Thomas W. Geisbert, Robert F. Garry, John S. Schieffelin, Donald S. Grant, Brian M. Sullivan   +12 more
doaj   +1 more source

Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs : involvement of MAPK and NF-κB pathways [PDF]

, 2014
The terpenoid 17-O-acetylacuminolide (AA) was shown to inhibit the production of several inflammatory mediators. However, the mechanisms by which this compound elicited its anti-inflammatory activity remain to be elucidated.
Achoui, Mouna, Haegeman, Guy, Heyninck, Karen, Looi, Chung Yeng, Mustafa, Ali Mohd, Mustafa, Mohd Rais   +5 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Association of Intercellular Adhesion Molecule 1 (ICAM1) with Diabetes and Diabetic Nephropathy

Frontiers in Endocrinology, 2013
Diabetes and diabetic nephropathy are complex diseases affected by genetic and environmental factors. Identification of the susceptibility genes and investigation of their roles may provide useful information for better understanding of the pathogenesis ...
Harvest F Gu, Jun eMa, Karolin T Gu, Kerstin eBrismar   +3 more
doaj   +1 more source

Melanoma-associated adhesion molecule MUC18/MCAM (CD146) and transcriptional regulator Mader in normal human CNS [PDF]

, 1998
The proteins MUC18 and Mader have been identified as markers of tumor progression in melanoma cells, MUC18, also known as MCAM (melanoma cell adhesion molecule) and as CD146 (endothelial antigen), is a cell adhesion molecule belonging to the ...
Ackenheil, Manfred, Hampel, Harald, Johnson, Judith P., Kirsch, Kathrin H., Körschenhausen, Dirk, Müller, Norbert, Penning, Randolph, Schwarz, Markus J.   +7 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Research advances of intercellular cell adhesion molecule-1 in IgA nephropathy

Linchuang shenzangbing zazhi, 2022
As a 90 kDa member of immunoglobulin superfamily in adhesion molecules， intercellular cell adhesion molecule-1 （ICAM-1） is the most widely studied of five ICAM molecules.
Wang Shan-shan, Zhang Xue-qin, Lu Chen
doaj  

Inflammatory mediators and cell adhesion molecules as indicators of severity of atherosclerosis: the Rotterdam Study [PDF]

, 2002
Inflammatory mediators and soluble cell adhesion molecules predict cardiovascular events. It is not clear whether they reflect the severity of underlying atherosclerotic disease.
Bots, M.L. (Michiel), Breteler, M.M.B. (Monique), Hofman, A. (Albert), Kiliaan, A.J. (Amanda), Maat, M.P.M. (Moniek) de, Meijer, J. (John), Witteman, J.C.M. (Jacqueline)   +6 more
core  

Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation. [PDF]

, 2014
RATIONALE: Anti-inflammatory and vascular protective actions of adiponectin are well recognized. However, many fundamental questions remain unanswered.
Booth, David, Gao, Erhe, Koch, Walter, Lau, Wayne Bond, Li, Jing-Jing, Ma, Xin-Liang, Preston, Kyle, Scalia, Rosario, Wang, Xiaoliang, Wang, Yajing, Yuan, Yuexing   +10 more
core   +2 more sources

Regulation of intercellular adhesion molecule-1 (CD54) gene expression [PDF]

Journal of Leukocyte Biology, 1999
Abstract Intercellular adhesion molecule-1 (ICAM-1, CD54) is an inducible cell adhesion glycoprotein of the immunoglobulin supergene family expressed on the surface of a wide variety of cell types. ICAM-1 interactions with the β2 integrins CD11a/CD18 (LFA-1) and CD11b/CD18 (MAC-1) on the surface of leukocytes are important for their ...
K A, Roebuck, A, Finnegan
openaire   +2 more sources