Results 21 to 30 of about 48,349 (272)
Animals, 2020 Collecting blood from an indwelling arterial catheter may reduce stress from repeated venipuncture in patients requiring serial monitoring, but the use of arterial blood for hematological and biochemical testing remains understudied.
Song Mi Lee +3 more
doaj +1 more source
Generalizing Consistency and other Constraint Properties to Quantified Constraints [PDF]
, 2007 Quantified constraints and Quantified Boolean Formulae are typically much more difficult to reason with than classical constraints, because quantifier alternation makes the usual notion of solution inappropriate.
Bordeaux, Lucas +2 more
core +2 more sources
Symmetry Breaking Using Value Precedence
, 2009 We present a comprehensive study of the use of value precedence constraints to break value symmetry. We first give a simple encoding of value precedence into ternary constraints that is both efficient and effective at breaking symmetry.
A. Adams +21 more
core +2 more sources
Biomolecules, 2018 The high demand for and resulting financial success of biopharmaceutical products over the last three decades have seen the door open for close copies of these biological products, also known as biosimilars.
Eva Rahman Kabir +2 more
doaj +1 more source
Successful implementation of interchange of biologic medications in chronic arthritis after information of costs to prescribers [PDF]
Exploration of Musculoskeletal DiseasesAim: To evaluate the impact of prescription, cost, and switching policy on the rate of switching from reference products to biosimilars. Methods: Analysis of an administrative database for prescription in a rheumatology division.
Fernando Perez-Ruiz +8 more
doaj +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Biologics and biosimilars in musculoskeletal diseases: addressing regulatory inconsistencies and clinical uncertainty [PDF]
Exploration of Musculoskeletal DiseasesBiologics are complex protein-based medications derived from living organisms, used primarily to treat immune-related diseases. Unlike small-molecule drugs synthesized from chemicals, biologics are produced using advanced biotechnology, making their ...
Lauren N. McGrath +2 more
doaj +1 more source
Bell's inequality test with time-delayed two-particle correlations [PDF]
, 2008 Adopting the frame of mesoscopic physics, we describe a Bell type experiment involving time-delayed two-particle correlation measurements. The indistinguishability of quantum particles results in a specific interference between different trajectories. We
A. V. Lebedev +3 more
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Concepts and Challenges of Biosimilars in Breast Cancer: The Emergence of Trastuzumab Biosimilars
Pharmaceutics, 2018 With the development of anti-human epidermal growth factor receptor 2 (HER2) monoclonal antibodies, trastuzumab-based therapy has become the standard of care among patients with early or advanced HER2-positive breast cancer. However, real-world data have
Alina Uifălean +5 more
doaj +1 more source