Results 51 to 60 of about 48,481 (274)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Recommendations on the procedure for determining the interchangeability of medicinal products

Регуляторные исследования и экспертиза лекарственных средств, 2018
The authors developed and presented recommendations on the procedure for determining the interchangeability of medicinal products. Interchangeability of drugs determined at the state registration of the medicinal product or when amendments to the ...
B. K. Romanov, N. D. Bunyatyan, Yu. V. Olefir, V. P. Bondarev, A. B. Prokofyev, R. I. Yagudina, R. N. Alyautdin, E. L. Kovaleva, A. P. Pereverzev, K. E. Zatolochina, A. S. Kazakov, A. V. Komratov, E. Yu. Pasternak   +12 more
doaj  

OnabotulinumtoxinA Displays Greater Biological Activity Compared to IncobotulinumtoxinA, Demonstrating Non-Interchangeability in Both In Vitro and In Vivo Assays

Toxins, 2020
Differences in botulinum neurotoxin manufacturing, formulation, and potency evaluation can impact dose and biological activity, which ultimately affect duration of action.
David Rupp, Greg Nicholson, David Canty, Joanne Wang, Catherine Rhéaume, Linh Le, Lance E. Steward, Mark Washburn, Birgitte P. Jacky, Ron S. Broide, Wolfgang G. Philipp-Dormston, Mitchell F. Brin, Amy Brideau-Andersen   +12 more
doaj   +1 more source

The Testable Implications of Zero-sum Games [PDF]

, 2009
We study Nash-rationalizable joint choice behavior under restriction on zero- sum games. We show that interchangeability of choice behavior is the only additional condition which distinguishes zero-sum games from general non-cooperative games with ...
Lee, Sangmok
core   +1 more source

An investigation of the relationship between thermal imaging and digital thermometer [PDF]

, 2015
BACKGROUND: A number of research papers and theoretical clinical models summarising how temperature of the skin over the knee may be altered according to different pathological processes have been published. Thermal imaging (TI) is generally regarded as
American Society for Testing and Material (ASTM), Ammer, Bland, Coughlan, Denoble, Dye, Gold, Lavery, Menard, Naslund, Ring, Ring, Sanchis-Alfonso, Sandow, Selfe, Selfe, Selfe, Selfe, Selfe, Selfe, Tootill   +20 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A Novel Approach to Artistic Textual Visualization via GAN

, 2017
While the visualization of statistical data tends to a mature technology, the visualization of textual data is still in its infancy, especially for the artistic text.
Ma, Muhan, Ma, Yichi
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source