Results 61 to 70 of about 502,493 (317)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Sequential Synthesis of Distributed Controllers for Cascade Interconnected Systems
, 2019 We consider the problem of designing distributed controllers to ensure passivity of a large-scale interconnection of linear subsystems connected in a cascade topology.
Agarwal, Etika +3 more
core +1 more source
Interconnection Networks for Scalable Quantum Computers [PDF]
, 2006 We show that the problem of communication in a quantum computer reduces to constructing reliable quantum channels by distributing high-fidelity EPR pairs. We develop analytical models of the latency, bandwidth, error rate and resource utilization of such
Isailovic, Nemanja +3 more
core +3 more sources
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Energies, 2020 The most critical positions of a prefabricated cable accessory, from the electrical point of view, are the interfaces between the stress cone and its surroundings.
Yi Luo +3 more
doaj +1 more source
Structural transition in interdependent networks with regular interconnections [PDF]
, 2018 Networks are often made up of several layers that exhibit diverse degrees of interdependencies. A multilayer interdependent network consists of a set of graphs $G$ that are interconnected through a weighted interconnection matrix $ B $, where the weight ...
Kooij, Robert E. +3 more
core +2 more sources
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
A Climbing System of Aerial Work Assistance Robot for UHV Tower
Zhongguo dianli, 2020 Aerial work is a high risk procedure in power grid construction and operation. It is a vital issue to protect the workers’ safety while working on high tower or climbing tower.
Shiyang TANG +4 more
doaj +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source