Results 61 to 70 of about 174,525 (257)

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

open access: yesFEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia   +9 more
wiley   +1 more source

Development, Governance, and Security: A Comparative Study of Successful and Fragile Modern States [PDF]

open access: yesThe Review of International Affairs
In the first quarter of the 21st century, despite all forms of social and other progress, the world has not achieved lasting peace. Social conflict and war, as its worst form, are as old as humanity itself, and it is increasingly evident that they will ...
Gordana Mišev, Petar Stanojević
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

The Influence of Real Estate on Its Surroundings Based on the Example of the Manufaktura Complex in Lodz

open access: yesReal Estate Management and Valuation, 2015
Real estate compared to other goods is distinguished by a high specificity. One of the signs of these specifics is the interdependence or correlation between property and its surroundings.
Olbińska Katarzyna
doaj   +1 more source

Generalized Synchronization Between ENSO and Hydrological Variables in Colombia: A Recurrence Quantification Approach

open access: yesFrontiers in Applied Mathematics and Statistics, 2020
We use Recurrence Quantification Analysis (RQA) to study features of Generalized Synchronization (GS) between El Niño-Southern Oscillation (ENSO) and monthly hydrological anomalies (HyAns) of rainfall and streamflows in Colombia.
Hernán D. Salas   +4 more
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

open access: yesFEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav   +4 more
wiley   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

open access: yesFEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

NEW REALITIES OF LABOR MARKET IN RUSSIA AND THEIR INFLUENCE ON COMPANY’S MANAGEMENT

open access: yesRussian Journal of Economics and Law, 2014
Objective: definition of the new realities in the system of recruitment of a modern company. Method: abstract-logic. Results: basing on assessing the opinions of various scholars in the studied area of activity, the need to review the recruitment system ...
E. I. Nesmeyanova
doaj  

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

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