Results 121 to 130 of about 12,814,514 (287)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Informational lobbying and activist resources: comparing mobilisations against school closures in Sweden

open access: yes, 2017
Information is often regarded as the main currency for interest group influence. However, studies explaining the use of informational lobbying tactics among interest groups are rare and the studies that do exist only focus on highly professionalised ...
Larsson Taghizadeh, Jonas,   +1 more
core   +1 more source

Interest Groups as an Alternative for Medical Education in Sleep Medicine: Experience Report at a Brazilian Medical School. [PDF]

open access: yesClocks Sleep, 2022
Pinto VLS   +7 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Networking vs. Allying: The Decision of Interest Groups to Join Coalitions in the US and the EU [PDF]

open access: yes, 2007
Ad hoc issue coalitions allow advocates to pool resources and signal support of their position to policymakers. Ad hoc coalitions, however, are not formed in every instance; groups do not always choose to ally since there are also costs associated with ...
Mahoney, Christine.
core  

La revendication d’une politique familiale : un mouvement québécois forgé dans le creuset de la Révolution tranquille, 1960-1990

open access: yesEnfances, Familles, Générations, 2012
A Quebec movement advocating family policies was created in the Sixties by family groups and social workers in private agencies whose activities were undermined by the creation of public welfare and educational systems.
Denise Lemieux
doaj  

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