Results 141 to 150 of about 9,379,501 (285)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Interest Groups and Health Facility Regulation - Future Directions for Health Policy and Systems Research Comment on "What Lies Behind Successful Regulation? A Qualitative Evaluation of Pilot Implementation of Kenya's Health Facility Inspection Reforms". [PDF]

Int J Health Policy Manag, 2023
Sriram V, Keshri VR.
europepmc   +1 more source

Interest groups and politics: The need to concentrate on group formation [PDF]

This paper assesses the development of the modeling of group behavior in the interest group literature. Throughout the literature, interest groups have been modeled in multiple ways: from passive groups that do not interact with one another to groups ...
Reuben E.
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Understanding the Value of a Proactive Telecare System in Supporting Older Adults' Independence at Home: Qualitative Interview Study Among Key Interest Groups.

J Med Internet Res, 2023
Fothergill L, Holland C, Latham Y, Hayes N.   +3 more
europepmc   +1 more source

Special Interest Groups and the Australia-United States Free Trade Agreement [PDF]

In the political economy model of Grossman and Helpman (1995), two incumbent governments attempt to negotiate a free trade agreement (FTA), while special interest groups in each country influence negotiations by offering financial contributions to their ...
Lukas M. Weber
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Representation-Influence Framework (RIF) for analyzing the roles of organized interest groups (OIGs) in environmental governance. [PDF]

MethodsX, 2021
Laraswati D, Krott M, Sahide MAK, Soraya E, Pratama AA, Rahayu S, Giessen L, Maryudi A.   +7 more
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Leveraging Lifestyle Medicine Interest Groups Through the COVID-19 Pandemic. [PDF]

Am J Lifestyle Med, 2021
Thompson LK, Znayenko-Miller T, Gorenstin D, Rastorguieva K, Bég S, Frates E, Frates B.   +6 more
europepmc   +1 more source