Results 21 to 30 of about 3,046,692 (210)
Development and Validation of a Wheel Wear and Rolling Contact Fatigue Damage Model [PDF]
, 2013 This paper summaries the development of a damage model to predict the deterioration rates of the wheel tread in terms of wear and rolling contact fatigue (RCF) damage.
Bevan, Adam +5 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2016 This chapter reviews the damage mechanisms operating in composite materials under repeated application of loads. Microscopic observations of the failure events are presented and the progression of damage is deduced. The effects of fiber stiffness, matrix
Talreja, Ramesh,, R. Talreja
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The digitization of this collection was funded by a gift from EBSCO ...
CANNOT READ--DAMAGE
core +5 more sources
Interface cavitation damage in polycrystalline copper
Acta Metallurgica et Materialia, 1992 Abstract Determination of an interface damage function (IDF) [Adams, Zhao and O'Hara, Acta metall. mater. 38 , 953 (1990)], from a stereological procedure similar to that presented by Hilliard [ Trans. Am. Inst. Min. Engrs 224 , 1201 (1963)], is described.
D.P. Field, B.L. Adams
openaire +2 more sources
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Ubiquitination at the interface of tumor viruses and DNA damage responses [PDF]
Current Opinion in Virology, 2018 Viruses exploit cellular ubiquitination machinery to shape the host proteome and promote productive infection. Among the cellular processes influenced by viral manipulation of ubiquitination is the DNA damage response (DDR), a network of cellular signaling pathways that sense and respond to genomic damage. This host-pathogen interaction is particularly
Joseph M Dybas +2 more
openaire +2 more sources