Results 61 to 70 of about 2,909,184 (279)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Shear-Mode Viscoelastic Damage Formulation Interface Element [PDF]

Key Engineering Materials, 2016
In this paper, a viscoelastic-damage cohesive zone model is formulated and discussed. The interface element constitutive law has two elastic and damage regimes. Viscoelastic behaviour has been assumed for the shear stress in the elastic regime. Three element Voigt model has been used for the formulation of relaxation modulus of the material.
Goodarzi, M. Saeed, Hosseini-Toudeshky, Hossein, Jalalvand, Meisam   +2 more
openaire   +5 more sources

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Damage analysis of brick-to-mortar interfaces

Procedia Engineering, 2011
AbstractA laboratory procedure aimed at generating a progressive deterioration of the interface between brick and mortar layers in controlled experimental conditions was developed at the Non Destructive Testing Laboratory of the Politecnico di Torino. It is intended as a preliminary stage in the design of a pre-qualification procedure to be applied to ...
ALBERTO, ANDREA, ANTONACI, PAOLA, VALENTE, Silvio   +2 more
openaire   +2 more sources

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Structural Health Monitoring and Interface Damage Detection for Infill Reinforced Concrete Walls in Seismic Retrofit of Reinforced Concrete Frames Using Piezoceramic-Based Transducers Under the Cyclic Loading

Applied Sciences, 2019
In this work, the piezoceramic-based transducers are used to perform the structural health monitoring (SHM) and interface damage detecting of non-ductile reinforced concrete (RC) frames retrofitted by post-installed RC walls. In order to develop the post-
Wen-I Liao, Fu-Pei Hsiao, Chien-Kuo Chiu, Chin-En Ho   +3 more
doaj   +1 more source

Mechanical characteristic variation of ballastless track in high-speed railway: effect of train–track interaction and environment loads

Railway Engineering Science, 2020
Due to the fact that ballastless tracks in high-speed railways are not only subjected to repeated train–track dynamic interaction loads, but also suffer from complex environmental loads, the fundamental understanding of mechanical performance of ...
Shengyang Zhu, Jun Luo, Mingze Wang, Chengbiao Cai   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source