Results 91 to 100 of about 6,653,655 (272)

A versatile interface model for thermal conduction phenomena and its numerical implementation by XFEM [PDF]

, 2014
A general interface model is presented for thermal conduction and characterized by two jump relations. The first one expresses that the temperature jump across an interface is proportional to the interfacial average of the normal heat flux while the ...
MONTEIRO, Eric, GU, ST, LIU, JT
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Morphosyntactic Study Of Urdu Esl Learners: A Derivation By Interface

The Journal of Studies in Language, Culture and Society
This study is an attempt to investigate the Urdu ESL leaners’ errors under the theoretical tent of Interface modular approach presented by the Noam Chomsky (1995).
Asad Ali , Aqsa Younis, Qaisar Jabbar , Sidra Niazi   +3 more
doaj  

Code-Switching by Phase

Languages, 2017
We show that the theoretical construct “phase” underlies a number of restrictions on code-switching, in particular those formalized under the Principle of Functional Restriction (González-Vilbazo 2005) and the Phonetic Form Interface Condition (MacSwan ...
Luis López, Artemis Alexiadou, Tonjes Veenstra   +2 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

SOME CONSIDERATIONS REGARDING ANALITICAL SOLVING OF THE REYNOLD’S EQUATION FROM FACE SEAL [PDF]

Fiabilitate şi Durabilitate, 2010
Taking into consideration a mechanical face seal which runs in hydrodynamic duty, we intend to understand what’s going on under its surfaces. Until nowadays the experimental study to measure the parameters of film between two seal surfaces is very ...
Nicolae POPA, Constantin ONESCU
doaj  

Overriding hypothesis's interface the right way

, 2016
Hypothes.is is an annotation framework that uses Pyramid to provide interface asset locations. This means that it is possible to override the interface and other components with one's own assets without simply forking the main hypothes.is repository. However, it's not actually completely clear how one does this.
openaire   +2 more sources

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source