Results 71 to 80 of about 4,046,373 (282)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

A bioelectromagnetic hypothesis of chronic primary pain: from thalamocortical dysrhythmia to the consciousness-brain interface

Frontiers in Pain Research
The World Health Organization's 2019 recognition in ICD-11 that chronic primary pain constitutes a disease in its own right demands novel conceptual frameworks. Current models focusing on peripheral and central sensitization, while valuable, may describe
Muhammad Khatib, Dror Robinson, Dror Robinson, Mustafa Yassin, Mustafa Yassin   +4 more
doaj   +1 more source

Analyzing the influence of reading purpose and translation experience on summary and translation tasks

Domínios de Lingu@gem, 2019
This paper analyzes the influence of reading purpose and translation experience on the interface of reading and translation processes. Since this interface has not been fully explored, we propose this exploratory-experimental study in order to analyze ...
Claudia Marchese Winfield, Norma Barbosa de Lima Fonseca, Lêda Maria Braga Tomitch   +2 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

The evolution of human-type consciousness – a by-product of mammalian innovation mechanism – a preliminary hypothesis

Frontiers in Psychology
Human consciousness is often viewed as one of the pinnacles of evolution, with most theories positioning it as an upgrade of pre-existing cognitive skills.
Uzi Ben Zvi
doaj   +1 more source

Grain levels in English path curvature descriptions and accompanying iconic gestures

Journal of Spatial Information Science, 2010
This paper confirms that the English verb system (similar to the Finnish, Dutch, and Bulgarian verb systems) represents path curvature at three different grain levels: neutral path curvature, global path curvature, and local path curvature.
Urpo Nikanne, Uta Sassenberg, Emile van der Zee   +2 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Endometrial Cancer Immune Escape Mechanisms: Let Us Learn From the Fetal–Maternal Interface

Frontiers in Oncology, 2020
The immune escape mechanisms at the base of tumor progression in endometrial cancer mimic immune tolerance mechanisms occurring at the maternal–fetal interface.
Valentina Bruno, Giacomo Corrado, Denisa Baci, Benito Chiofalo, Maria Antonia Carosi, Livia Ronchetti, Emilio Piccione, Adriana Albini, Adriana Albini, Douglas M. Noonan, Douglas M. Noonan, Giulia Piaggio, Enrico Vizza   +12 more
doaj   +1 more source