Results 51 to 60 of about 229,445 (257)

Complement at the Nano–Neuroimmune Interface: A Hypothesis-Driven Perspective on Opioid Use Disorder

Immuno
The complement system is a central component of innate immunity with established roles in host defense and emerging functions in neurodevelopment, synaptic remodeling, and neuroimmune communication within the central nervous system (CNS).
Alexander Jacob, Harbir Singh, Poolakkad S. Satheeshkumar, Aum Champaneri, Rahul K. Das, Ravi K. Aalinkeel, Supriya D. Mahajan, Jessy J. Alexander   +7 more
doaj   +1 more source

Global rescue of defects in HIV-1 envelope glycoprotein incorporation: implications for matrix structure. [PDF]

PLoS Pathogens, 2013
The matrix (MA) domain of HIV-1 Gag plays key roles in membrane targeting of Gag, and envelope (Env) glycoprotein incorporation into virions. Although a trimeric MA structure has been available since 1996, evidence for functional MA trimers has been ...
Philip R Tedbury, Sherimay D Ablan, Eric O Freed   +2 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Renumerating wh-compound questions in Japanese at the syntax-morphology interface

Glossa
In this paper, we investigate wh-compound questions in Japanese to adjudicate between lexicalist and non-lexicalist approaches to word formation. We first show that wh-compound questions pass standard diagnostic tests for wordhood in Japanese, thereby ...
Hisako Ikawa, Yosuke Sato
doaj   +2 more sources

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Overriding hypothesis's interface the right way

, 2016
Hypothes.is is an annotation framework that uses Pyramid to provide interface asset locations. This means that it is possible to override the interface and other components with one's own assets without simply forking the main hypothes.is repository. However, it's not actually completely clear how one does this.
openaire   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Analyzing the influence of reading purpose and translation experience on summary and translation tasks

Domínios de Lingu@gem, 2019
This paper analyzes the influence of reading purpose and translation experience on the interface of reading and translation processes. Since this interface has not been fully explored, we propose this exploratory-experimental study in order to analyze ...
Claudia Marchese Winfield, Norma Barbosa de Lima Fonseca, Lêda Maria Braga Tomitch   +2 more
doaj   +1 more source

Characterization of spatiotemporal electroactive anodic biofilm activity distribution using 1D simulations

Scientific Reports, 2022
Activity distribution limitation in electroactive biofilm remains an unclear phenomenon. Some observations using confocal microscopy have shown notable difference between activity close to the anode and activity at the liquid interface. A numerical model
Pierre Belleville, Gerard Merlin, Julien Ramousse, Jonathan Deseure   +3 more
doaj   +1 more source