Results 61 to 70 of about 236,428 (250)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Grain levels in English path curvature descriptions and accompanying iconic gestures

Journal of Spatial Information Science, 2010
This paper confirms that the English verb system (similar to the Finnish, Dutch, and Bulgarian verb systems) represents path curvature at three different grain levels: neutral path curvature, global path curvature, and local path curvature.
Urpo Nikanne, Uta Sassenberg, Emile van der Zee   +2 more
doaj   +1 more source

Endometrial Cancer Immune Escape Mechanisms: Let Us Learn From the Fetal–Maternal Interface

Frontiers in Oncology, 2020
The immune escape mechanisms at the base of tumor progression in endometrial cancer mimic immune tolerance mechanisms occurring at the maternal–fetal interface.
Valentina Bruno, Giacomo Corrado, Denisa Baci, Benito Chiofalo, Maria Antonia Carosi, Livia Ronchetti, Emilio Piccione, Adriana Albini, Adriana Albini, Douglas M. Noonan, Douglas M. Noonan, Giulia Piaggio, Enrico Vizza   +12 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

The evolution of human-type consciousness – a by-product of mammalian innovation mechanism – a preliminary hypothesis

Frontiers in Psychology
Human consciousness is often viewed as one of the pinnacles of evolution, with most theories positioning it as an upgrade of pre-existing cognitive skills.
Uzi Ben Zvi
doaj   +1 more source

Syntactic Structures and the Conscious Awareness of Language Experience. An Intermediate Level Hypothesis

Rivista Internazionale di Filosofia e Psicologia, 2014
In this article we review the basic idea of the “intermediate level” hypothesis about consciousness as proposed by Ray Jackendoff, then developed by Crick and Koch and finally by Prinz.
Francesco Marchi, Giacomo Romano
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Morphosyntactic Study Of Urdu Esl Learners: A Derivation By Interface

The Journal of Studies in Language, Culture and Society
This study is an attempt to investigate the Urdu ESL leaners’ errors under the theoretical tent of Interface modular approach presented by the Noam Chomsky (1995).
Asad Ali , Aqsa Younis, Qaisar Jabbar , Sidra Niazi   +3 more
doaj  

Code-Switching by Phase

Languages, 2017
We show that the theoretical construct “phase” underlies a number of restrictions on code-switching, in particular those formalized under the Principle of Functional Restriction (González-Vilbazo 2005) and the Phonetic Form Interface Condition (MacSwan ...
Luis López, Artemis Alexiadou, Tonjes Veenstra   +2 more
doaj   +1 more source