Results 81 to 90 of about 6,653,655 (272)
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
DFM synthesis approach based on product-process interface modelling. Application to the peen forming process. [PDF]
, 2010 Engineering design approach are curently CAD-centred design process. Manufacturing information is selected and assessed very late in the design process and above all as a reactive task instead of being proactive to lead the design choices. DFM appraoches
F. Cochennec +8 more
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Grain levels in English path curvature descriptions and accompanying iconic gestures
Journal of Spatial Information Science, 2010 This paper confirms that the English verb system (similar to the Finnish, Dutch, and Bulgarian verb systems) represents path curvature at three different grain levels: neutral path curvature, global path curvature, and local path curvature.
Urpo Nikanne +2 more
doaj +1 more source
What is the source of L1 attrition? The effect of recent L1 re-exposure on Spanish speakers under L1 attrition [PDF]
, 2015 The recent hypothesis that L1 attrition affects the ability to process interface structures but not knowledge representations (Sorace, 2011) is tested by investigating the effects of recent L1 re-exposure on antecedent preferences for Spanish pronominal ...
Sturt, Patrick +2 more
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Frontiers in PsychologyHuman consciousness is often viewed as one of the pinnacles of evolution, with most theories positioning it as an upgrade of pre-existing cognitive skills.
Uzi Ben Zvi
doaj +1 more source
Rivista Internazionale di Filosofia e Psicologia, 2014 In this article we review the basic idea of the “intermediate level” hypothesis about consciousness as proposed by Ray Jackendoff, then developed by Crick and Koch and finally by Prinz.
Francesco Marchi, Giacomo Romano
doaj +1 more source
Endometrial Cancer Immune Escape Mechanisms: Let Us Learn From the Fetal–Maternal Interface
Frontiers in Oncology, 2020 The immune escape mechanisms at the base of tumor progression in endometrial cancer mimic immune tolerance mechanisms occurring at the maternal–fetal interface.
Valentina Bruno +12 more
doaj +1 more source