Results 41 to 50 of about 6,653,655 (272)
Structural and dynamic requirements for optimal activity of the essential bacterial enzyme dihydrodipicolinate synthase. [PDF]
PLoS Computational Biology, 2012 Dihydrodipicolinate synthase (DHDPS) is an essential enzyme involved in the lysine biosynthesis pathway. DHDPS from E. coli is a homotetramer consisting of a 'dimer of dimers', with the catalytic residues found at the tight-dimer interface ...
C F Reboul +6 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Novel concept of a modular hip implant could contribute to less implant failure in THA: a hypothesis
Patient Safety in Surgery, 2018 Background The modularity in total hip arthroplasty (THA) allows orthopaedic surgeons for an exact reconstruction of hip biomechanical parameters especially in revision and tumor arthroplasty. Modular structured femoral stems using taper junctions showed
Ronny Grunert +7 more
doaj +1 more source
Surfactant mixtures at the oil–water interface [PDF]
, 2013 NOTICE: this is the author’s version of a work that was accepted for publication in Journal of Colloid and Interface Science. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other ...
Webster, JRP +14 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The L2 Acquisition of French Interrogatives: Pragmatic Inferences in Clefted wh-Questions
Languages, 2021 The present study aims to elaborate on the understanding of the second language (L2) acquisition of French interrogatives by focusing on clefted (subject) wh-questions, structures that are largely absent in prior L2 literature.
Emilie Destruel, Bryan Donaldson
doaj +1 more source
BMC Psychiatry, 2018 BackgroundDespite its popularity as an inferential framework, classical null hypothesis significance testing (NHST) has several restrictions. Bayesian analysis can be used to complement NHST, however, this approach has been underutilized largely due to a
D. Quintana, Donald R. Williams
semanticscholar +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The subject realization in L2 Spanish by German L1 speakers
IsoglossThis article deals with the realization of referential subjects in the L2 Spanish of German (adult) native speakers. The acquisition of a null subject grammar by speakers of a non-null subject language has drawn considerable attention in generative ...
Anna Kocher
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source