Results 41 to 50 of about 4,046,373 (282)
BMC Psychiatry, 2018 BackgroundDespite its popularity as an inferential framework, classical null hypothesis significance testing (NHST) has several restrictions. Bayesian analysis can be used to complement NHST, however, this approach has been underutilized largely due to a
D. Quintana, Donald R. Williams
semanticscholar +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
The subject realization in L2 Spanish by German L1 speakers
IsoglossThis article deals with the realization of referential subjects in the L2 Spanish of German (adult) native speakers. The acquisition of a null subject grammar by speakers of a non-null subject language has drawn considerable attention in generative ...
Anna Kocher
doaj +1 more source
The L2 Acquisition of French Interrogatives: Pragmatic Inferences in Clefted wh-Questions
Languages, 2021 The present study aims to elaborate on the understanding of the second language (L2) acquisition of French interrogatives by focusing on clefted (subject) wh-questions, structures that are largely absent in prior L2 literature.
Emilie Destruel, Bryan Donaldson
doaj +1 more source
Nouns for visual objects: A hypothesis of the vision-language interface
Language Sciences, 2019 Abstract We propose an interpretation of the vision process and a structural analysis of nouns and nominal reference which make it possible to relate the visual/cognitive and the linguistic encapsulation of objecthood in a rigorous way. The result of this integrated hypothesis is a predictive account of possible and impossible nouns lexicalizing ...
Francesco-Alessio Ursini +1 more
openaire +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Parametrical Study of Freshwater–Saltwater Interface Dynamic
Modelling and Simulation in Engineering, 2023 In this paper, a saltwater intrusion model, in view to study the dynamics of the interface between the saltwater and the freshwater in a coastal aquifer, is established. This dynamic is caused by an injection of saltwater and a freshwater pumping through
Mody Lo, Daouda Sangare
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The Plant Cell, 2017 ePlant for hypothesis generation permits the exploration of plant data across >12 orders of magnitude encompassing >20 different kinds of genome-wide data, all in one easy-to-use, open-source tool.
Jamie Waese +14 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source