Results 121 to 130 of about 3,810,567 (377)
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Energy Level Alignment at Interfaces in Metal Halide Perovskite Solar Cells
Advanced Materials Interfaces, 2018 The rapid progress of organic–inorganic metal halide perovskite solar cells (PSCs) has attracted broad interest in photovoltaic community. A typical PSC consists of anode/cathode, a perovskite layer as absorber, and carrier transport layer(s) (electron ...
Shenghao Wang +3 more
semanticscholar +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Controlling molecular transport in minimal emulsions
Nature Communications, 2016 Emulsion droplets have many biotechnological applications, such as parallelized single cell analysis. Here, Gruner et al. introduce the concept of the minimal emulsions in a microfluidic device that allows full control of molecular transport between ...
Philipp Gruner +6 more
doaj +1 more source
Discurso, mídias e ensino: caminhos possíveis
Linha D'Água, 2015 O processo de ensino-aprendizagem não pode ignorar as transformações pelas quais passa a realidade. É preciso que a escola se aproxime dos fatos reais e os traga para a sala de aula, promovendo uma reflexão sobre eles.
Sandro Luis Silva
doaj +1 more source
Delay Properties of Energy Efficient Ethernet Networks
, 2017 Networking operational costs and environmental concerns have lately driven the quest for energy efficient equipment. In wired networks, energy efficient Ethernet (EEE) interfaces can greatly reduce power demands when compared to regular Ethernet ...
Alonso, Sergio Herrería +3 more
core +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
First-Principles Studies of Hydrogen Adsorption at Pd-SiO2 Interfaces
Sensors, 2015 The interaction of hydrogen with Pd-SiO2 interfaces has been investigated for the first time using first-principles calculations based on density functional theory.
Yoshihiro Irokawa, Mamoru Usami
doaj +1 more source
, 2008 Polarized neutron reflectivity measurements of a ferromagnetic [(LaMnO$_3$)$_{11.8}$/(SrMnO$_3$)$_{4.4}$]$_6$ superlattice reveal a modulated magnetic structure with an enhanced magnetization at the interfaces where LaMnO$_3$ was deposited on SrMnO$_3 ...
A. B. Shah +9 more
core +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source